GENETICS OF DRUG RESISTANCE, ANTIGENIC VARIATION AND DIS

寄生虫病实验室的疟疾遗传科专注于恶性疟原虫，这种寄生虫导致了人类最严重的疟疾形式。我们的研究包括以下项目：*确定和表征对氯喹和奎宁等主要抗疟疾药物的反应所涉及的因素。*在Aotus疟疾模型中确定恶性疟原虫传染性的基因座的图谱。*解剖调节var基因表达的基因控制，这些基因负责抗原变异和逃避宿主免疫系统。*现场和实验室研究血红蛋白C和S对恶性疟疾的保护作用。这些项目的工作包括连锁作图、人口调查、基因操作和基因产物分析等策略。这些发现为疾病的诊断、治疗和控制措施的发展提供了基本的生物学信息。

The Malaria Genetics Section of the Laboratory of Parasitic Diseases focuses on Plasmodium falciparum, the parasite that causes the most severe form of human malaria. Our research includes the following projects: * Identification and characterization of the factors involved in responses to such major antimalarial drugs as chloroquine and quinine. * Mapping of loci that determine P. falciparum infectivity in the Aotus malaria model. * Dissection of the gene controls that regulate expression of var genes responsible for antigenic variation and evasion of the host immune system. * Field and laboratory investigations of the protection conferred by hemoglobins C and S against the severe forms of falciparum malaria. The work in these projects incorporates strategies of linkage mapping, population surveys, gene manipulation, and gene product analysis. The findings provide fundamental biological information for the development of diagnostics, therapeutics, and control measures against the disease.