DNA probes containing solvatochromic fluorescent tags

我希望加入Tucker小组，在那里我承担了我的硕士项目。该小组的研究包括改良的DNA和DNA传感。该小组已经开发出一种用于检测SNPs的菲DNA传感器。在这项工作之后，我感兴趣的项目包括开发标记为DNA的萘酰亚胺作为检测癌细胞的传感器。该传感器将是定量的，检测碱基改变的百分比，这对确定细胞是否为癌细胞非常重要。荧光将通过紫外线吸收和TM研究来监测，这是我在整个硕士项目中执行它们后熟悉的技术。这些传感器具有令人兴奋的临床应用可能性，可以在手术过程中移除癌症组织。癌变组织会发出荧光，很容易从周围的健康组织中切除。

I wish to be attached to the Tucker group, where I undertook my masters project. The group's research comprises of modified DNA and DNA sensing. The group have developed an anthracene DNA sensor for the detection of SNPs. Following on from this work, the project of interest to me consists of developing naphthalimide tagged DNA as a sensor to detect cancer cells. The sensor will be quantitative, detecting the percentage of changed bases, which is important for determining whether the cell is cancerous. Fluorescence will be monitored by UV absorption and TM studies, techniques which I am familiar with after performing them throughout my masters project. These sensors have exciting possibilities to be used clinically, removing cancerous tissue during operations. The cancerous tissue would fluoresce allowing easy excision from the surrounding healthy tissue.