Mitochondrial and synaptic dysfunction in neurons from patients with OPA1- associated parkinsonism

该项目的重点是识别和了解调控线粒体质量控制途径的新机制，这些机制在包括帕金森氏病和阿尔茨海默病在内的各种神经退行性疾病中受到影响。在该项目的第一部分，将开发一种高含量的有丝分裂筛选，以识别人类神经母细胞瘤细胞中的这些新途径。然后，所有的命中结果都将得到验证，任何发现都将被翻译到帕金森氏病患者的IPSC来源的神经元中，以确定任何相关的潜在治疗靶点。

The project focuses on identifying and understanding novel mechanisms regulating mitochondrial quality control pathways, which are affected in a variety of neurodegenerative diseases, including Parkinson's Disease and Alzheimer's Disease. In the first part of the project, a high content mitophagy screen will be developed to identify these novel pathways in human neuroblastoma cells. All hits will then be validated and any discovery will be translated in iPSC-derived neurons from Parkinson's Disease patients, to identify any relevant potential therapeutic targets.