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ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME

ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME
抗磷脂综合征中的抗心磷脂抗体
批准号：
6532956
负责人：
POJEN P CHEN
金额：
$25.17万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-02-25 至 2004-04-14
来源：
https://reporter.nih.gov/project-details/6532956
关键词：
antiphospholipid syndrome autoimmune disorder biomimetics cardiolipins clinical research diagnostic tests enzyme linked immunosorbent assay female human subject immunoglobulin G immunopathology laboratory mouse monoclonal antibody phospholipids pregnancy loss systemic lupus erythematosus technology /technique development thrombosis

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中文摘要
翻译
描述：(改编自《调查者摘要》)：目标1是生成 并鉴定了10种免疫球蛋白单克隆性ACL。目标2是分析单克隆ACL在 体内胎儿丢失模型。目标3是识别和描述 致病性前交叉韧带的模拟。目标4是做免疫学和功能性的 APS患者抗模拟物抗体的研究。目标5是申请 模拟实验研究APS患者和对照组的致病性前交叉韧带
英文摘要
DESCRIPTION: (Adapted from the Investigator's Abstract): Aim 1 is to generate and characterize 10 IgG monoclonal aCLs. Aim 2 is to analyze monoclonal aCLs in the in vivo fetal loss model. Aim 3 is to identify and characterize the mimetics for pathogenic aCL. Aim 4 is to do immunological and functional studies of antibodies against mimetics in APS patients. Aim 5 is to apply mimetics to study pathogenic aCL in APS patients and controls.
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