In Utero Cocaine Exposure: Child Neurocognitive Outcome

描述：(申请人提供) 孕期接触可卡因的儿童与未接触可卡因的儿童没有区别 对大多数传统的认知和行为指标进行控制。然而，动物 数据显示可卡因对发育中的神经系统有显著影响 表明孕期接触可卡因的儿童将 与对照不同的是，当认知被分析时，它的独特之处 神经认知系统。拟议的为期5年的研究将调查这一影响 妊娠期可卡因暴露对神经认知功能的影响，检查神经 神经认知功能(FMRI)的基础，并探索早期物质使用在 孩子们。本研究的具体目的是：(1)确定 宫内可卡因暴露对神经认知系统影响最大(S)；(2)至 可卡因暴露和非暴露儿童的fMRI表现 他们的神经认知测试；(3)监测物质使用的获得 和其他冒险行为；(4)识别神经认知特征 与早期药物使用有关；以及(5)探索早期药物使用的神经基础。 吸毒。关于增长、发展、社会和经济发展的背景资料 情绪功能、家庭动力和物质使用的习得 风险承担行为将从标准化的医疗和 心理评估。适合使用的神经心理学任务 儿童将提供神经认知系统的行为分析。功能磁共振成像将 提供有关孕期接触可卡因的神经基础的信息和 早期使用药物。紧随其后的是120名市中心儿童， 出生，年龄9-11岁，一半孕期接触可卡因将是 实施了一系列的医学、心理学和神经认知 措施。120名儿童中的50名还将接受功能磁共振成像，这将得到 在研究期间进行了两次：一次是在早期，作为基线，一次是在 青春期。将涉及三个调查小组：PI和小组 来自阿尔伯特·爱因斯坦医学中心将保持纵向随访 受试者和评估受试者的早期药物使用和其他风险 行为；来自认知神经科学中心的合作者和团队 宾夕法尼亚大学正在合作进行神经认知 评估；费城儿童医院团队正在合作 以获取功能磁共振数据。这项调查既有可能获得 详细了解妊娠对神经认知和神经的影响 可卡因暴露，以及直接调查和干预 年轻的孩子似乎注定要在早期吸毒，可能还会上瘾。

DESCRIPTION: (provided by applicant) Children with gestational cocaine exposure do not differ from non-exposed controls on most traditional measures of cognition and behavior. Yet, animal data demonstrating significant cocaine effects on the developing nervous system of the fetus suggest that children with gestational cocaine exposure will differ from controls when cognition is analyzed in terms its distinct neurocognitive systems. The proposed 5-year study will investigate the effect of gestational cocaine exposure on neurocognitive function, examine neural bases of neurocognitive function (fMRI), and explore early substance use in children. The specific aims of this research are: (1) to identify the neurocognitive system(s) most impacted by in utero cocaine exposure; (2) to correlate fMRI findings of both cocaine-exposed and non-exposed children with their neurocognitive assays; (3) to monitor the acquisition of substance use and other risk-taking behaviors; (4) to identify neurocognitive profiles associated with early drug use; and (5) to explore the neural bases of early drug use. Background information regarding growth, development, social and emotional functioning, family dynamics, and acquisition of substance use and risk-taking behaviors will be obtained from standardized medical and psychological assessments. Neuropsychological tasks adapted for use with children will provide behavioral assays of neurocognitive systems. fMRI will provide information about the neural bases of gestational cocaine exposure and early substance use. A cohort of 120 inner city children, followed, since birth, ages 9-11 years, half with gestational cocaine exposure will be administered the battery of medical, psychological, and neurocognitive measures. Fifty of the 120 children will also have fMRI, which will be obtained twice during the study: once early on, as baseline, and once during adolescence. Three teams of investigators will be involved: The PI and team from Albert Einstein Medical Center will maintain longitudinal follow-up of subjects and assess subjects for acquisition of early drug use and other risk behaviors; the Co-PI and team from the Center for Cognitive Neuroscience at the University of Pennsylvania are collaborating to carry out neurocognitive assessments; and the Children's Hospital of Philadelphia team are collaborating to obtain fMRI data. This investigation has both the potential to gain a detailed understanding of the neurocognitive and neural effects of gestational cocaine exposure, as well as to direct investigations and interventions for young children seemingly destined for early drug use and, possibly, addiction.