Nanocrystalline Coatings for Dental TMJ Implants

描述(申请人提供)：物理系、口腔修复与生物材料系、口腔颌面部系 UAB的外科提出了一项评估纳米晶体的跨学科计划 用于牙科植入物的涂层。我们建议检验一种假设，即 TMJ种植体的骨固定特性 通过操纵纳米结构可以显著改进器件 金刚石涂层(附着力和磨损)和羟基磷灰石涂层(固定)。 表面粗糙度仅为5-10 nm的纳米金刚石涂层将被 由微波等离子体化学气相沉积工艺生产 甲烷/氢/氮物种。我们初步的粘附力和韧性 研究表明，150公斤以下的钻石颗粒没有剪切破坏/松动 压痕加载。纳米磷酸钙(主要是羟基磷灰石) 涂层将通过脉冲激光沉积技术沉积在 螺丝和器械表面与骨头接触。化学精准控制 并且薄涂层的结构应该产生更理想的表面 用骨头固定。将对制服实施新的设计策略 通过旋转和平移种植体在曲面上进行涂层 激活的血浆。纳米结构钻石和羟基磷灰石可以界面连接 在同一植入物上，只要在高温下沉积金刚石 首先用脉冲低温沉积羟基磷灰石 激光。将进行纳米压痕研究，以测量模数和 涂层的硬度以及模拟牙科条件下的磨损试验。 纳米结构金刚石与钙的体内生物相容性测试 磷酸盐陶瓷将使用标准化的模型系统进行， 包括注射微粒碎片，外加软硬组织 微粒和植入物的评估。体内部分将进行 与UAB的口腔和颌面临床医生/外科医生合作，世卫组织 积极参与TMJ外科重建领域。

DESCRIPTION (provided by applicant): The Departments of Physics, Dental Prosthodontics and Biomaterials, and Department of Oral and Maxillofacial Surgery at UAB propose an interdisciplinary program to evaluate nanocrystalline coatings for dental implants. We propose to test the hypothesis that the wear and bone fixation characteristics of TMJ (temporomandibular joint) implant devices can be significantly improved by manipulation of the nanostructure of diamond coatings (adhesion and wear) and hydroxyapatite coatings (fixation). Nanocrystalline diamond coatings with surface roughness of only 5-10 nm will be produced by microwave plasma chemical vapor deposition process with methane/hydrogen/nitrogen species. Our preliminary adhesion and toughness studies have shown no shear failure/loosening of diamond particles up to 150 kg indentation load. Nanocrystalline calcium phosphate (primarily hydroxyapatite) coatings will be deposited by pulsed laser deposition techniques onto the screws and device surfaces in contact with bone. Precise control of chemistry and structure of the thin coating should result in a more optimum surface for fixation with bone. Novel design strategies will be implemented for uniform coating over curved surfaces by rotation and translation of the implant in the activated plasma. Nanostructured -diamond and -hydroxyapatite can be interfaced on the same implant, provided diamond deposition at high temperature is done first followed by a low temperature deposition of hydroxyapatite using pulsed lasers. Nanoindentation studies will be carried out to measure the modulus and hardness of coatings as well as wear testing under simulated dental conditions. In vivo biocompatibility testing of nanostructured diamond and calcium phosphate ceramics will be carried out using standardized model systems, including injection of particulate debris, plus soft and hard tissue evaluations of particulates and implants. The in vivo part will be carried out in collaboration with an oral and maxillofacial clinician/surgeon at UAB, who actively participates in the area of TMJ surgical reconstruction.