CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY

这个核心的主要目标是开发分析方法 暴露与宿主因素在疾病反应中的关系 协助研究核心和另一个核心内的其他中心成员 统计方法的应用。最后，核心包括 作为培养现代统计学研究生的目标之一 方法：研究方法。 核心成员对他们的工作有长期的、实质性的支持 来自美国国立卫生研究院。四个大型研究项目目前是这个核心的重点。 这些包括：癌症流行病学中与时间有关的因素，方法学 遗传流行病学、统计学方法与空气污染研究 暴露测量误差的流行病学和处理方法。总而言之， 病例，研究设计、统计和流行病学中的重要问题是 正在通过开发新的方法来解决。所有问题都是 这项工作涉及的是与接触以下物质对人类健康造成的后果有关的问题 环境毒物。该小组每周开会，审查最近的 活动和非正式研讨会。研究生也被包括在内，所以他们 可以讨论他们的工作并接受教职员工的反馈。外在的 互动主要是与呼吸效应研究核心。它 似乎正在进行更多的工作来连接呼吸道 以分子生物学和分子生物学为核心的效应暴露评估研究 样品处理和生物统计设施的核心。

The main goals of this Core are to develop methods for analyzing relationships between exposure and host factors in the disease response and to assist other Center members both within the Research Core and another Cores in the application of the statistical methodologies. Finally the Core includes as one of its objectives training of graduate students in modern statistical methods. Core members have long-standing, substantial support for their work primarily from NIH. Four large research projects are currently the focus of this Core. These include: time related factors in cancer epidemiology, methodologic research in genetic epidemiology, statistical methods and air pollution epidemiology and methods for dealing with exposure measurement error. In all cases, significant issues in study design, statistics and epidemiology are being addressed by the development of new approaches. All the issues being addressed in this work are related to human health consequences of exposure to environmental toxicants. The group meets weekly for reviews of recent activities and an informal seminar. Graduate students are included so they can discuss their work and receive feedback from the faculty. The external interactions are primarily with the Respiratory Effects Research Core. It appears that additional work is underway to tie together the respiratory Effects Exposure Assessment Research Core with the Molecular Biology and Sample Processing, and Biostatistics Facility Cores.