CORE--EXPOSURE AND HEALTH EFFECTS

这个项目在莫顿·李普曼博士的指导下， 包括18个活跃的项目，由5名全职和3名 兼职会员。该研究项目的主要目标是 改进评估人类接触的科学基础和技术， 运用最先进的知识建立直接关系 在人类暴露于环境毒物中， 以及可直接测量的健康结果。一系列活动， 从空气采样和分析方法开发扩展到体内 保留测量和微环境建模包括在内。的 研究了吸入毒物内剂量的决定因素 通过对局部和支气管内颗粒和气相沉积的研究 和清除，并通过放射性核素代谢研究。实地研究 在自然界中， 人群，特别是涉及环境空气暴露的人群， 生理和症状反应。

This program, under the direction of Dr. Morton Lippmann, includes eighteen active projects being conducted by five full-time and three part-time members. The primary objective of this research program is to improve the scientific basis and techniques for assessing human exposure, and to apply state-of-the-art knowledge for establishing direct relationships among human exposure to environmental toxicants, resulting doses to target sites, and their directly measurable health outcomes. A range of activities, extending from air sampling and analytical methods development to in-vivo retention measurements and micro-environmental modeling is included. The factors determining internal dose from inhaled toxicants are investigated through studies of regional and intrabronchial particle and vapor deposition and clearance, and through studies in radionuclide metabolism. Field studies are also being conducted of exposure-response relationships in natural populations, especially those involving ambient air exposures and physiological and symptomatic responses.