CORE--STUDY DESIGN AND STATISTICAL METHODOLOGY

描述：本核心的主要目标是开发分析方法， 疾病反应中暴露与宿主因素之间的关系， 协助研究核心和其他核心内的其他中心成员， 统计方法的应用。最后，核心包括 作为其目标之一，培养研究生在现代统计 方法. 核心成员的工作主要得到长期、实质性的支持 来自NIH。四个大型研究项目目前是该核心的重点。 这些包括：癌症流行病学中的时间相关因素，方法学 遗传流行病学、统计方法和空气污染研究 流行病学和处理暴露测量误差的方法。在所有 病例，研究设计，统计学和流行病学中的重要问题是 正在通过制定新的方法加以解决。所有的问题 在这项工作中涉及的是人类健康的后果， 环境毒物该小组每周开会审查最近的 活动和非正式研讨会。研究生也包括在内， 可以讨论他们的工作，并从教师那里得到反馈。外部 主要是与呼吸影响研究中心的相互作用。它 似乎正在进行额外的工作， 以分子生物学为核心的接触效应评价研究 样本处理和生物统计设施核心。

Description: The main goals of this Core are to develop methods for analyzing relationships between exposure and host factors in the disease response and to assist other Center members both within the Research Core and another Cores in the application of the statistical methodologies. Finally the Core includes as one of its objectives training of graduate students in modern statistical methods. Core members have long-standing, substantial support for their work primarily from NIH. Four large research projects are currently the focus of this Core. These include: time related factors in cancer epidemiology, methodologic research in genetic epidemiology, statistical methods and air pollution epidemiology and methods for dealing with exposure measurement error. In all cases, significant issues in study design, statistics and epidemiology are being addressed by the development of new approaches. All the issues being addressed in this work are related to human health consequences of exposure to environmental toxicants. The group meets weekly for reviews of recent activities and an informal seminar. Graduate students are included so they can discuss their work and receive feedback from the faculty. The external interactions are primarily with the Respiratory Effects Research Core. It appears that additional work is underway to tie together the respiratory Effects Exposure Assessment Research Core with the Molecular Biology and Sample Processing, and Biostatistics Facility Cores.