TOTAL SYNTHESIS OF POLYCYCLIC NATURAL PRODUCTS

描述：(首席研究人员摘要)尽管化学家已经成为 相当擅长构建少量非常复杂的分子，我们 通常不能在高效、 实用、性价比高的方式。我们普遍不能怀孕和 执行实际的实验室合成是我们科学的一个弱点。它 这项研究的长期目标是通过探索 复杂有机结构实验室合成的新策略。这个 要合成的化合物是自然界的分子-生物碱、碳水化合物、 异戊二烯类化合物和乙酸根素。其目的不仅仅是制造化合物，而且是为了 以一种能教会我们一些关于架构方面的新东西的方式来做 构建分子的能力。特定的合成靶标是圆柱胺、不协调 D、沙拉菌素A、巴豆胺、头孢他丁12、真甲状腺素A-C、阿诺胺A-B、 卤化氯、品甲酸和牛磺酸。 在这方面开展的研究的基本意义 工程就是提高我们的综合能力。就是因为这个原因 我们识别新的有机结构，并努力发现不明显的， 用商业上可用的积木组装它们的有效方法。 作为合成化学家，我们的最终目标是能够合成任何想要的东西 有机分子，无论多么复杂，以一种能够 商业化生产。然而，我们选择的许多目标都有 内在的生物学重要性，而我们的合成研究可能会 迫在眉睫的实际重要性。在这些目标中有不一致的D， 头孢菌素12和卤代氯，化合物非常罕见，以至于不足以 材料可用于全面的活体评估。至合计 综合：我们希望能解决这个问题。

DESCRIPTION: (Principal Investigator's Abstract) Although chemists have become rather adept at constructing small amounts of very complicated molecules, we generally cannot prepare most desired organic compounds in an efficient , practical, and cost-effective manner. Our general inability to conceive and execute practical laboratory syntheses constitutes a frailty of our science. It is the long-term goal of this research to address this deficiency by exploring new strategies for the laboratory synthesis of complex organic structures. The compounds to be synthesized are molecules of Nature-alkaloids, carbohydrates, isoprenoids, and acetogenins. The intent is not just to make compounds, but to do it in a way that will teach us something new about the architectural aspect of molecule-building. Specific synthetic targets are cylindramide, discorhabdin D, sarain A, croomine, cephalostatin 12, euthyroideones A-C, arnoamines A-B, halichlorine, pinnaic acid, and tauropinnaic acid. The fundamental significance of the kind of research being carried out in this project is the improvement of our synthetic abilities. It is for this reason that we identify novel organic structures and strive to discover non-obvious, efficient methods to assemble them from commercially-available building blocks. Our ultimate goal as synthetic chemists is to be able to synthesize any desired organic molecule, no matter how complex, in a manner that would be ameanable to commercial production. However, many of the targets we have chosen have intrinsic biological importance, and our synthetic research might have immediate practical importance. Among these targets are discorhabdin D, cephalostatin 12, and halichlorine, compounds so rare that insufficient material is available for full scale in vivo evaluation. Through total synthesis we hope to remedy this problem.