PATIENT-ORIENTED ENVIRONMENT HEALTH RESEARCH & TRAINING

这个以病人为中心的研究的职业生涯中期研究人员奖的首要目标是扩大耶鲁大学专注于环境健康的临床多学科研究的培训。候选人Carrie A.Redlich，医学博士，公共卫生硕士，医学副教授，是一位备受尊敬的临床调查员，在多学科环境/职业健康研究方面拥有独特的培训和研究经验。这项建议将使Redlich博士能够扩大她目前的研究努力，并开发一个专注于环境和职业健康(EOH)的指导计划，并整合实验室、临床和流行病学方法(也称为生物标记物研究、分子流行病学或转化研究)。拟议的研究项目是雷德利希博士正在进行的研究的继续。具体目标是：1)在现场流行病学研究中确定决定/修改异氰酸酯哮喘风险的暴露和宿主因素；2)确定如何最好地诊断异氰酸酯哮喘以及它在汽车修车业中的流行程度；3)研究异氰酸酯导致异氰酸酯哮喘的机制；4)基于T细胞或其他免疫反应，确定免疫致敏或异氰酸酯哮喘的外周血液标志物；5)建立具有人类异氰酸酯显著特征的HDI哮喘小鼠模型。指导计划的目标是为职业和环境医学研究员、博士后和博士后、医学生和其他实习生提供以患者为导向的环境健康研究方面的研究指导。该计划将包括教学培训，包括生物标记物研究的新课程，研究基础设施(数据分析、研究辅助、信息系统)，以及实践和监督良好的研究指导。耶鲁大学EOH研究的环境横跨临床、公共卫生和基础科学系，为多学科协作环境健康研究和培训提供了理想的环境。

The overarching goal of this midcareer investigator award in patient-oriented research is to expand training in clinical multidisciplinary research focused on environmental health at Yale University. The candidate, Carrie A. Redlich, MD, MPH, an Associate Professor of Medicine, is a well respected clinical investigator with unique training and research experience in multidisciplinary environmental/occupational health research. This proposal will enable Dr. Redlich to expand her current research efforts and to develop a mentoring program that focuses on environmental and occupational health (EOH), and integrates laboratory, clinical and epidemiologic approaches (also known as biomarker research, molecular epidemiology, or translational research). The proposed research project is a continuation of Dr Redlich's ongoing research. Specific aims are: 1) Characterize exposure and host factors which determine/modify risk of isocyanate asthma in a field epidemiologic study of HDI exposed autobody shop workers; 2) Determine how best to diagnose isocyanate asthma and how prevalent it is in autobody shop industry; 3) Investigate the mechanisms by which isocyanates cause isocyanate asthma; 4) Based on T cell or other immunologic responses, identify peripheral blood markers of immune sensitization or isocyanate asthma; 5) Develop a murine model of HDI asthma with the salient features of human isocyanate. The goals of the mentorship program are to provide research mentorship in patient-oriented environmental health research to occupational and environmental medicine fellows, doctoral and postdoctoral students, medical students and other trainees. The program will include didactic training, including new courses in biomarker research, a research infrastructure (data analysis, research assistance, information systems), and hands-on well supervised research mentorship. The environment for EOH research at Yale, spanning clinical, public health, and basic science departments, provides an ideal setting for multidisciplinary collaborative environmental health research and training.