The role of sodium channels in neocortical dendrites

描述(由申请人提供)： 这项拟议研究的具体目的是调查 电压调节钠通道在动作电位反向传播中的作用 新皮质细胞的树突。具体来说，我们将确定是否 钠通道中缓慢失活的调制是导致 钠通道可用性的增加是反向传播的基础 动作电位转化为树突。我们将检验的假设是(1)和 钠通道可用性的增加是树突状的基础 响应于高频放电的电生成，以及(2)调制 细胞信号通路中的钠通道是导致脑血管紧张素转换酶 导致通道增加的缓慢停用的稳态概率 可用性。这项拟议的研究与健康相关的是 传播是突触效能的重要调节因子。了解 反向传播的生物物理基础将有助于研究人员了解 学习和记忆的生理机制。

DESCRIPTION (provided by applicant): The specific aims of the proposed research are to investigate the role of voltagegated sodium channels in back-propagation of action potentials in the dendrites of neocortical cells. Specifically, we will determine whether modulation of slow inactivation in sodium channels is responsible for an increase in sodium channel availability that underlies back propagation of action potentials into dendrites. The hypotheses we will test are that (1) an increase in sodium channel availability is the basis for dendritic electrogenesis in response to high frequency discharges, and (2) modulation of sodium channels by cell signaling pathways is responsible for an decrease in steady-state probability of slow inactivation which leads to increased channel availability. The health-relatedness of the proposed research is that back propagation is an important regulator of synaptic efficacy. Understanding the biophysical basis for back propagation will help researchers understand the physiological mechanisms of learning and memory.