COMPUTER MODEL DVMT: CELLULAR & POPULATION AIDS EPIDEMIOLOGY: AFRICAN AMERICANS

本项目由三个相互联系、相辅相成的 生物医学计算基础设施开发活动， 研究和推广。 研究部分侧重于计算机 科学实验，目前被称为 计算流行病学。 我们的目标是建立在现有的 在流行病学建模和生物医学领域的优势 信息管理系统。 研究将强调 CD 4+淋巴细胞群体的综合计算模型， HIV病毒载量相互作用，以检查 单独和/或组合的干预（药物）疗法。 目标是：（a）加强和扩大生物医学 塔斯基吉大学研究的计算基础设施; B）携带 结合理论和临床HIV/CD 4+细胞的研究 人口的相互作用，并使用计算模型， 评价抗逆转录病毒干预战略，重点是 非裔美国人;以及，c）通过创建虚拟 健康信息资源，重点是少数群体的健康， 依靠互联网和暴力侵害妇女作为主要模式， 沟通和信息共享。 该项目将于 两个阶段。 在第一阶段（1-2年），合作和数据库 发展将得到重视。 与香港大学合作 亚拉巴马医学院，在那里进行了广泛的艾滋病毒/艾滋病临床研究， 正在进行中，Wlill提供获得临床和分子 将用于建模研究的实验室数据。 同相 H（2-5年），基于高级复合物的流行病学建模研究 将采用量化方法。 在这两个阶段， 创建虚拟健康信息的基础架构组件 将创建资源。 它将作为一种核心资源， 生物医学科学研究和教育;促进合作 研究;通过互联网获取数字信息， 并提供计算建模实验室， 本科生和研究生，包括那些谁将 攻读博士学位。

This project consists of three interrelated and complimentary activities of biomedical computing infrastructure development, research and outreach. The research component focuses on computer based scientific experimentation currently referred to as computational epidenuiology. The goal is to build on our existing strength in the area of epidemiologic modeling and biomedical information management systems. The research will emphasizes integrative computational models for CD4+ lymphocyte populations and HIV viral load interactions so as to examine the effect of intervention (drug) therapies individually and/or in combinations. The objectives are to: a) strengthen and expand the biomedical computing infrastructure for research at Tuskegee University; b) carry out research that combines theoretical and clinical HIV/CD4+ cell population interactions and to use the computational models to evaluate antiretroviral intervention strategies with a focus on African Americans; and, c) provide outreach by creating a Virtual Health Information Resource with a focus on the health of minorities, relying on the Internet and the VAW as the primary- mode for communication and information sharing. The project will proceed in two phases. In Phase I (years 1-2), collaboration and database development will be emphasized. Collaboration with the University of Alabama Medical School, where extensive clinical HIV/AlDS studies are being carried out, Wlill provide access to clinical and molecular laboratory data that will be used in the modeling research.. In Phase H (years 2-5), epidemiologic modeling research based on advanced comp utational methods will be conducted. In both phases, an outreach and infrastructure component to create a Virtual Health Information Resource will be created. It will serve as a core resource to advance biomedical sciences research and education; promote collaborative research; enable access to digital information via the Internet and the WWW and provide computational modeling laboratory for undergraduate and graduate students including those who will be pursuing PhD studies.