COMPUTATIONAL BIOLOGY & BIOINFORMATICS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目侧重于计算生物学和生物信息学的基础设施发展，作为塔斯基吉大学生物医学研究中心(CBR)核心资源的一部分。涉及先进信息技术、互联网和数据库的研究对于检查和分析疾病发生模式、遗传特征和分子水平动力学至关重要。我们在核心生物信息学的努力中的关键战略是提升我们科学家在计算生物学和生物信息学方面的基础设施和专业知识，获得先进的计算和网络资源，并促进在健康差距研究中利用这些技术的积极研究。服务器开发：我们已经迁移到Linux服务器(Red Hat Enterprise Linux ES)。我们已将所有数据移动到新服务器中。我们还在服务器上放置了一些软件，以便TU园区的计算机可以访问。网站开发：一个新的网站开发已经完成，将进行测试，很快就会上线。我们还开始了基线链接和数据，供对生物信息学和健康差异领域感兴趣的科学家使用。研究协调网络(RCN)：讨论了一段时间以来与蒙哥马利艾滋病外展(MAO)的合作，现在已同意与MAO建立伙伴关系，并制定详细的协议，从阿拉巴马州的黑带县(BBC)收集数据。赞助第六届年度生物医学研究专题讨论会：作为促进共享正在进行的生物医学研究活动以及解决处理健康差距问题的战略的一部分，CCEBRA于2005年9月29-30日在塔斯基吉大学凯洛格会议中心举办了第六届年度生物医学研究专题讨论会。共享资源：CCEBRA一直为理工大学的教职员工和科研人员提供统计分析服务。开发了与健康差距项目有关的共享数据来源，其中包括艾滋病毒/艾滋病、婴儿死亡率、癌症、糖尿病和心血管疾病，供阿拉巴马州和其他比较县的BBC使用。使用地理信息系统工具创建汇总表、图表和地图。提供数据库(硬拷贝和电子格式)，供需要信息的科学家共享，以推动涉及阿拉巴马州健康差距研究的生物医学研究，特别关注阿拉巴马州的黑带和农村县。NCBI在塔斯基吉大学提交的指南：国家医学图书馆下属的国家生物技术信息中心(NCBI)在为生物医学研究社区建立有用的生物信息学资源方面走在了前列，包括PubMed、GenBank、Entrez等。在2006年8月27日的那一周，我们在塔斯基吉大学的中心将举办一门名为《基因库和NCBI分子生物学资源的现场指南》的课程。该课程将由NCBI的讲师授课。还将张贴及时的提醒。该研讨会面向塔斯基吉大学RCMI的科学家和教职员工，以及来自塔斯基吉大学校园其他地区的学生。NCBI的出席证书也将颁发给研讨会的参与者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses upon Infrastructure development in Computational Biology and Bioinformatics as part of the Core Resources at the Center for Biomedical Research (CBR) at Tuskegee University. Research involving advanced information technologies, the Internet and databases is crucial in examining and analyzing patterns of disease occurrence, genetic traits and molecular level dynamics. The key strategy in our endeavors in the core Bioinformatics is to upgrade the infrastructure and expertise of our scientists in computational biology and bioinformatics, acquire advanced computational and network resources and promote active research that exploits these technologies in health disparity studies. Server Development: We have migrated to a Linux server (Red Hat Enterprise Linux ES). We have moved all our data into the new server. We have also put some of the software on the server to be accessible to computers on the TU campus. Website development: A new website development has been completed and will be tested and soon be online. We have also started the base line links and data to be used for scientists interested in the area of Bioinformatics and Health disparities. Research Coordination Network (RCN): Discussed collaboration with Montgomery Aids Outreach (MAO) over some period of time and have now agreed upon a partnership with MAO with detailed protocol to collect data from the black belt counties (BBC) of Alabama. Sponsoring the sixth annual biomedical research symposium: As part of the strategy to promote sharing of biomedical research activities that are in progress as well as to address national issues dealing with Health Disparities, CCEBRA has organized the sixth annual biomedical research symposium that was held September 29-30, 2005 at the Kellogg Conference Center, Tuskegee University. Shared Resource: CCEBRA has been providing service in statistical analysis for faculties and researchers in TU. Developed sharable data sources related to the health disparities project that included HIV/AIDS, infant mortality rate, cancer, diabetes and cardiovascular diseases for the BBC in Alabama as well as other comparison counties. Created summary tables, graphs and maps using GIS tools. Made the databases available (hardcopy and electronic formats) to be shared by scientists who need information to advance biomedical research dealing with health disparities studies in Alabama with a special focus on the Black Belt and rural counties of Alabama. NCBI filed guide in Tuskegee University: The National Center for Biotechnology Information (NCBI), a division of the National Library of Medicine has led the way in establishing useful bioinformatics resources for the biomedical research community, including PubMed, GenBank, Entrez and others. In the week of August 27, 2006, our center at Tuskegee University will host a course entitled "A Field Guide to GenBank and NCBI Molecular Biology Resources". The course will be given by instructors from NCBI. Timely reminders will also be posted. The seminar is intended for Tuskegee University RCMI scientists and faculty, staff and students from other areas of the Tuskegee University campus. Certificates of Attendance from NCBI will also be given to workshop participants.