Appl of Microarray Tech to Understanding the Mechanism o

基因组学的进步导致了数千个人类基因的定义以及非人类生物体中相当大比例的基因的鉴定。我们正在利用这些先进的基因组资源，加上现代工程和信息学能力，建立和维护一个国家的最先进的cDNA微阵列中心实验室。微阵列允许在数千个基因中同时监测相对于对照样品的基因表达变化。这个小组的目标是促进我们对环境因子如何影响基因表达的理解，从而增加我们对这些因子作用机制的了解，重点是了解非致突变致癌物的作用机制，了解氧化应激在不良健康影响中的作用，并了解对环境因子的遗传易感性。

The advance of genomics has led to the definition of thousands of human genes as well as the identification of a significant proportion of genes in non-human organisms. We are utilizing these advanced genomic resources coupled with modern engineering and informatics capabilities to establish and maintain a state-of-the-art cDNA microarray center laboratory. Microarrays allow for the simultaneous monitoring of gene expression changes relative to control samples in thousands of genes. It is the goal of this group to advance our understanding of how environmental agents may affect gene expression, and thus increase our knowledge of the mechanism of action of such agents, with a priority focused on understanding the mechanism of action of non-mutagenic carcinogens, understanding the role of oxidant stress in adverse health effects, and understanding genetic susceptibility to environmental agents.