Cardiovascular Chemoreflex-Baroreflex Interaction

描述（由申请人提供）：我的研究计划的主要重点 就是了解自主神经系统是如何调节人体 心血管系统这项拨款申请的总体目标是提高 了解外周和中枢化学反射如何改变动脉 人体压力感受器反射功能，集中于肌肉交感神经活动 和心率化学感受性反射和压力感受性反射在控制神经元的活动中起主要作用。 通过它们对自主神经系统的深刻影响， 外流然而，这些强大的反射系统的相互作用并不是 人类完全理解。在这方面，具体目标是 补助金申请旨在解决以下问题：1）是否 等二氧化碳呼吸过度改变人动脉压力感受性反射功能？2a）是否 等二氧化碳低氧改变人动脉压力感受性反射功能？（2）是否 选择性外周化学感受器兴奋剂阿米三嗪模拟的影响， 缺氧对人体动脉压力感受性反射功能影响？3)高氧低碳酸血症 改变人类动脉压力感受器反射功能在本申请中，我们 利用最先进的方法，并提出高度对照的研究， 有意识的人类志愿者，探索动物研究提出的问题， 区这些研究将促进我们对心血管疾病的基本认识。 调节以及它是如何被化学反射的变化所改变的 刺激.此外，这些研究将提供一个基础的 理解这将是必要的解释相关的病理生理学， 心力衰竭慢性阻塞性肺病和睡眠呼吸暂停通过实现这些目标，我们将 将目前仅在动物身上获得的见解扩展到一个知之甚少的领域， 人类心血管调节的区域。

DESCRIPTION (provided by applicant): The primary focus of my research program is to understand how the autonomic nervous system regulates the human cardiovascular system. The overall goal of this grant application is to enhance understanding of how the peripheral and central chemoreflexes modify arterial baroreflex function in humans, focusing on muscle sympathetic nerve activity and heart rate. Chemoreflexes and baroreflexes play a major role in control of the cardiovascular system via the profound influences they exert on autonomic outflow. However, the interaction of these powerful reflex systems is not completely understood in humans. In this Context, the specific aims for this grant application are designed to address the following questions: 1) Does isocapnic hyperpnea alter arterial baroreflex function in humans? 2a) Does isocapnic hypoxia alter arterial baroreflex function in humans? 2b) Does the selective peripheral chemoreceptor stimulant almitrine mimic the effects of hypoxia on arterial baroreflex function in humans? 3) Does hyperoxic hypocapnia alter arterial baroreflex function in humans? Throughout this application, we exploit state-of-the-art methods and propose highly controlled studies in conscious human volunteers, probing questions raised by animal studies in this area. These studies will advance our understanding of basic cardiovascular regulation in humans and how it is modified by changes in chemoreflex stimulation. Further, these studies will provide a foundation of basic understanding that will be necessary to explain related pathophysiologies such as heart failure, COPD, and sleep apnea. By addressing these aims, we will extend insights that are now only available in animals to a poorly understood area of cardiovascular regulation in humans.