Efferent Connections of the Hippocampal Field CA1

拟议项目的长期目标是澄清来自海马区CA1区域的投影的组织。为了实现这一目标，我们提议在大鼠中进行三组特定的实验：1)使用顺行示踪剂PHAL详细研究CA1区到外侧隔复合体、下丘和内嗅区的轴突投射；2)使用逆行示踪剂荧光金研究CA1区的神经输入；3)分析海马区中隔颞轴投射的地形组织。更好地了解CA1涉及的回路和这些投射的组织将有助于更好地了解海马体作为一个整体，以及它如何与其他系统相互作用来控制目标定向行为。这样的认识最终将在治疗某些与衰老、疾病和创伤相关的疾病方面取得突破。

The long-range goal of the proposed project is to clarify the organization of projections from field CAI of the hippocampus. To accomplish this goal, three specific groups of experiments in the rat are proposed: 1) A detailed study of axonal projections from field CAI to the lateral septal complex, to the subiculum, and to the entorhinal area using the anterograde tracer, PHAL; 2) A study of neural inputs to field CAI using the retrograde tracer, fluorogold; 3) An analysis of the topographic organization of projections along the septotemporal axis of the hippocampus. A better understanding of the circuitry in which field CA 1 is involved and the organization of these projections will lead to a better understanding of the hippocampus as a whole and how it interacts with other systems to control goal-directed behavior. Such understanding will eventually lead to breakthroughs in the treatment of certain disorders related to aging, diseases, and trauma.