Conference on Wnt and Beta Catenin Signaling

描述（由申请人提供）： 研究胚胎发育的分子机制， 人类疾病的原因揭示了类似的信号转导 途径在这两个过程中发挥关键作用。 Wnt信号通路， 激活B-连环蛋白证实了这一原理。 这条路最初是 被鉴定为果蝇胚胎中体节极性的调节因子， 在促进小鼠乳腺肿瘤的参与。 但最近的 研究还表明，调节B-连环蛋白功能的突变 与多种人类癌症有关，包括黑色素瘤和 结肠直肠癌 这次会议将是第一次专业组织的会议， 多学科会议特别关注Wnt信号传导。 它将 积极地将那些研究涉及Wnt的人类癌症的人聚集在一起， pathway途径，基础研究人员对该途径如何正常运作感兴趣， 以及那些有兴趣确定Wnt如何 通路与癌症有关，以及如何开发治疗方法。 的 本次会议的主要目标是促进 这些不同的研究人员，以确定新的屏幕或 潜在抗癌药物的靶点， 参与疾病过程，以及对正常功能的新见解， Wnt信号通路。 组织者一直在这一领域，因为它的 成立，并代表学术和生物技术的利益。 鉴于 在这一领域的研究爆炸性增长，由于其连接到各种 癌症，这是非常及时的会议，共同关注 Wnt和B-catenin信号在发育和疾病中的作用。

DESCRIPTION (provided by applicant): Research into the molecular mechanisms of embryonic development and into the causes of human diseases have revealed that similar signal transduction pathways play key roles in both processes. The Wnt signaling pathway that activates B-catenin exemplifies this principle. This pathway was initially identified as a regulator of segment polarity in Drosophila embryos, and based on its involvement in promoting mammary tumors in the mouse. However, recent work has also demonstrated that mutations that regulate B-catenin functions are involved in a wide range of human cancers, including melanoma and colorectal cancer. This meeting would be the first professionally-organized multidisciplinary meeting focused specifically on Wnt signaling. It would actively bring together those working on human cancers involving the Wnt pathway, basic researchers interested in how the pathway normally functions, and those from biotechnology companies interested in identifying how the Wnt pathways are linked to cancer, and how therapies can be developed. The primary goal of this meeting is to foster discussions and interactions between these various investigators, with the goal of identifying new screens or targets for potential anti-cancer drugs, new genes that are potentially involved in disease processes, and new insights into the normal functions of Wnt signaling pathways. The organizers have been in this field since its inception, and represent both academic and biotechnology interests. Given the explosive growth in research in this field owing to its connection to various cancers, it is extremely timely to have a meeting with the joint focus on the roles of Wnt and B-catenin signaling in both development and disease.