HEART-LUNG PHYSIOLOGY: MOLECULAR-SYSTEMIC INTEGRATION

这是一个新的应用程序，培养研究生和博士后研究员在综合生理学的心血管和呼吸系统。该计划的目标是为选定的一组博士前和博士后学员提供在分子，细胞，器官和整个动物和人类水平上整合心肺系统功能的强化和优秀培训。拟议计划的主要优势是培训教师的可用性及其研究动物心肺系统生理学的能力，并有针对性地操纵基因，将遗传和分子生物学信息整合到生理功能中。有19名教师参与该计划，来自凯斯西储大学（CWRU）医学院的6个基础和2个临床科学系。这些包括生理学和生物物理学，神经科学，营养学，生物医学工程，解剖学，生物化学，医学和儿科学。许多参与的教师有长期富有成效的合作互动，并以跨学科的方式培养了一些成功的研究和医生科学家。他们都有活跃的和基础良好的实验室提供最先进的研究培训，在心肺生理学使用人类和/或动物模型。该培训计划将成为一种机制，将这些研究人员聚集在一起，并将对培训和未来的心肺生理学研究产生重大影响。本申请寻求八名博士前和/或博士后学员。博士预科生将被录取为博士。学生在一个新开发的系统集成生理学研究生课程。博士前培训包括专门为心肺生理学、分子和细胞生物学基础、实验室轮换、研讨会和指导研究的综合方面设计的高级课程。本项目的博士后培训生分为三种类型：1）MD进入专业博士;计划; 2）心脏病学和/或肺临床研究员接受2年全职研究作为博士后培训生; 3）博士学位。博士后研究生。特别的高级课程，积极的研讨会和期刊俱乐部将补充博士后培训。我们相信，我们提出的培训计划，强调跨部门的障碍和科学学科是必要的研究人员在心肺系统生理学的综合方面的成功培训。

This is a new application for training graduate and post-doctoral fellows in integrated physiology of cardiovascular and respiratory systems. The goal of this program is to provide a selected group of pre and postdoctoral trainees with intensive and excellent training in integration of function of the cardio-respiratory systems at the molecular, cellular, organ and whole animal and human levels. The major strength of the proposed program is the availability of training faculty and their ability to study physiology of the cardio-respiratory systems in animals with targeted manipulation of genes allowing integration of genetic and molecular biological information into physiological functions. There are 19 participating faculty in this program from 6 basic and 2 clinical science departments at the School of Medicine at Case Western Reserve University (CWRU). These include Physiology & Biophysics, Neurosciences, Nutrition, Biomedical Engineering, Anatomy, Biochemistry, Medicine, and Pediatrics. Many of the participating faculty has long term productive collaborative interactions and trained a number of successful research and physician-scientists in an interdisciplinary manner. They all have active and well-founded laboratories providing state-of-the-art research training in cardiopulmonary physiology using human and/or animal models. This training program will be a mechanism to bring together these investigators and will have a major impact on training and future research in cardio-pulmonary physiology. This application seeks eight pre- and/or postdoctoral trainees. The predoctoral students will be enrolled as Ph.D. students in a newly developed Systems Integrated Physiology graduate program. Predoctoral training includes advanced courses specifically designed for integrated aspects of cardio- respiratory physiology, fundamentals of molecular and cell biology, laboratory rotations, seminars, and guided research. Postdoctoral trainees in this program are of three kinds: 1) MD's entering a specialized Ph.D. program; 2) cardiology and/or pulmonary clinical fellows receiving 2 years full time research as postdoctoral trainees; 3) Ph.D. postdoctoral trainees. Special advanced courses, active seminar sessions and journal clubs will supplement postdoctoral training. We believe, our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines is necessary for the successful training of researchers in integrated aspects of the physiology of the cardio-respiratory systems.