TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY

提出了一个在发育生物学方面的博士前和博士后研究培训计划，重点是细胞，分子和遗传机制。该计划是跨部门的，多学科的，涉及教师和学员在弗吉尼亚大学，主要来自生物学系在艺术和科学学院和细胞生物学，微生物学和神经科学计划在医学院。目前的培训支持提供给教师在发育生物学是不够的，和拟议的培训计划被视为一个令人兴奋的和扩大的大学范围内的努力，在发育生物学，其中包括一个重要组成部分：1）新聘教师的研究和培训的兴趣，在发育生物学和相关领域的细胞和分子生物学，生物化学和发育遗传学; 2）由大学和NSF支持的重大改造项目，使发展学院的实验室达到现代标准，为培训提供优良的设施; 3）发展生物学计划的形成，一个跨部门的组织，其目标是促进发展生物学家之间更强有力的研究和培训互动与合作加强对研究生和博士后研究人员的招聘和指导。培训教师是多样的，但互补的，并提供广泛的，但在关键领域的综合培训。这些包括基因表达的调节、细胞信号传导、细胞和组织相互作用、胚胎诱导和图案化、细胞决定和分化以及形态发生的许多方面，如细胞膜融合、细胞-基质相互作用、细胞骨架、细胞运动性、细胞粘附和细胞极性。使用的系统包括果蝇、蚱蜢、两栖动物、鸟类、小鼠、培养细胞和几种植物。采用遗传、分子、细胞、生理和生物物理方法，重点是遗传学。大多数工作是基础科学，但在医学院的临床部门完成的几个项目具有医学应用。因此，教师提供了广阔的视野，广泛的研究机会，以及丰富的培训和职业发展环境。在过去，他们一直非常成功地培养前和博士后学生的独立研究生涯。申请资助10名博士前和6名博士后受训人员，通过竞争授予最有前途的候选人。研究生或博士后学习的前3年，如果在培训中取得了良好的进展，或获得个人奖励，将得到支持。

A pre-doctoral and post-doctoral research training program in developmental biology with an emphasis on cellular, molecular, and genetic mechanisms is proposed. The program is interdepartmental, multi- disciplinary, and involves faculty and trainees at the University of Virginia, primarily from the Departments of Biology in the College of Arts and Sciences and from Cell Biology, Microbiology, and the Neurosciences Program in the School of Medicine. The current training support available to faculty in developmental biology is inadequate, and the proposed training program is seen as an important part of an exciting and expanding University-wide effort in developmental biology that involves: 1) new hires of faculty with research and training interests in developmental biology and in related areas of cell and molecular biology biochemistry and developmental genetics; 2) major renovation projects, supported by the University and the NSF, that have brought the laboratories of development faculty up to modern standards providing excellent facilities for training; 3) formation of the Developmental Biology Program, an interdepartmental organization with the goals of fostering stronger research and training interactions and collaborations among developmental biologists and to carry out more productive recruiting and mentoring of graduate students and post- doctoral researchers. The training faculty are diverse but complementary are diverse but complementary, and offer broad but integrated training in key areas. These include regulation of gene expression, cell signaling, cell and tissue interactions, embryonic induction and patterning, cell determination and differentiation, and many aspects of morphogenesis, such as cell membrane fusion, cell-matrix interaction, cytoskeleton, cell motility, cell adhesion, and cell polarity. The systems used include Drosophila, grasshopper, amphibians, birds, mice, cultured cells, and several plants. Genetic, molecular, cellular, physiological and biophysical approaches are used, with a strong emphasis in genetics. Most work is basic science but several projects, done in clinical departments of the School of Medicine, have medical applications. Thus the faculty provide a broad perspective, a wide selection of research opportunities, and a rich environment for training and career development. In the past they have been highly successful in training both pre and post-doctoral students for independent research careers. Funds are requested for 10 pre-doctoral and 6 postdoctoral trainees to be awarded competitively to the most promising candidates. Support will be for the fist 3 years of graduate student or post- doctoral study, with the condition of good progress in training, or until individual awards are obtained.