CELLULAR AND MOLECULAR RESPONSES IN LUNG DISEASE

该计划的主要目标是培养年轻的医生-科学家在肺部研究的全职学术生涯。重点将放在发展和培养高素质的受训人员上，使他们能够获得成为独立调查员所需的必要知识和技能。这项研究将在犹他州大学医学、儿科、生物学、生物化学、病理学或人类遗传学系活跃的高级研究人员的个人指导下进行。该培训计划利用了遗传学和分子生物学大学的优势，同时以患者为导向的研究与正在进行的急性肺损伤研究，特别是急性呼吸窘迫综合征（ARDS）。我们的研究培训理念是，这样的培训可以最好地实现学员和教师导师谁已经证明了成功的准备个人的职业生涯在研究之间的最直接的日常互动的基础上。一个非常有利的环境，多学科的方法存在，由于密切的合作关系已经发展之间的各种导师和不断发展的协会和合作。导师研究培训将辅以正式的课程工作，讲座，会议，研讨会和其他相关的教育形式，以准备学员制定创新和有价值的研究计划，在肺部疾病的培训结束。拟议的导师代表了一群活跃的科学家，他们从事与肺部健康和疾病相关的五个相互关联的主题领域的研究。每个导师都有一个NIH资助的生产性研究项目。专题领域包括：1）白细胞生物学; 2）血管细胞生物学; 3）发育生物学和衰老; 4）人类遗传疾病; 5）以患者为导向的研究。我们相信，该计划将使学员掌握现代生物医学研究的复杂性，并将提供对研究医学问题所需的跨学科合作方法的赞赏。

The primary goal of this proposed program is to train young physician- scientists for a full-time academic career in pulmonary research. The emphasis will be placed on developing and cultivating highly qualified trainees, allowing them to acquire the necessary knowledge and skills required to evolve as independent investigators. The research will be conducted under the personal preceptorship of active senior investigators in the departments of Medicine, Pediatrics, Biology, Biochemistry, Pathology or Human Genetics at the University of Utah. The training program utilizes established strengths at the University of genetics and molecular biology while the patient-oriented research is aligned with ongoing investigations in acute lung injury, in particular the Acute Respiratory Distress Syndrome (ARDS). Our research training philosophy is that such training can best be achieved on the basis of the most direct day-to-day interaction between trainees and faculty preceptors who have demonstrated success in preparing individuals for careers in research. A highly conducive environment for a multi- disciplinary approach exists due to the close collaborative ties already developed among various preceptors and evolving associations and collaborations. The preceptorial research training will be supplemented with formal course work, lectures, conferences, seminars, and other pertinent educational modalities in order to prepare the trainees to formulate innovative and meritorious research programs in pulmonary diseases at the conclusion of their training. The proposed preceptors represent a group of active scientists engaged in research in five interrelated thematic areas relevant to lung health and disease. Each preceptor has an NIH-funded productive research program. The thematic areas include: 1) Leukocyte Biology; 2) Vascular Cell Biology; 3) Developmental Biology and Aging; 4) Human Genetic Diseases; and 5) Patient-Oriented Research. We believe the program will enable the trainees to master the complexities of modern biomedical research, and will provide an appreciation for the collaborative interdisciplinary approach required for research into medical problems.