Organization of memory processes in the human brain

描述：该项目将使用功能磁共振成像来 研究前额叶记忆操作的性质和组织 人脑的大脑皮质(PFC)和内侧颞叶(MTL)。虽然 传统上，PFC与工作记忆联系在一起，MTL与情节联系在一起 记忆，最近的神经成像研究表明，这种区别可能并不完全 捕捉这些不同形式的记忆之间的关系。这项建议 我将研究PFC和MTL在工作记忆中的参与以及以后的研究 情景记忆的形成，特别是探索记忆的本质 在PFC和MTL内由不同的亚区调节的过程。它是 假设PFC和MTL中都存在基于流程的组织 使得信息的维护将从神经上分离 项目之间的操作和集成。实验1将考察 PFC和MTL的征聘也有类似的程序基础，使用 事件相关功能磁共振成像(FMRI)分析以确定 预测未来基于项目和关系记忆的区域。实验2将 通过以下方法研究腹外侧和背外侧PFC手术的性质 探索干扰如何调节PFC的激活。实验3-4将 检查PFC和MTL中的进程特定激活是否在 通过区分以下区域来学习和测试上下文 与项的内存相关联，以及与 项与其上下文和/或源之间的关联。这些研究应该 用于阐明PFC和MTL助记符的性质和共性 过程，进一步加深了我们对这些关键结构的理解 易患阿尔茨海默病？S和帕金森？S病、精神分裂症和健康 衰老。

DESCRIPTION: This project will use functional magnetic resonance imaging to examine the nature and organization of memory operations in the prefrontal cortex (PFC) and medial temporal lobe (MTL) of the human brain. Although traditionally PFC has been associated with working memory and MTL with episodic memory, recent neuroimaging studies suggest that this distinction may not fully capture the relations across these different forms of memory. This proposal will examine the involvement of PFC and MTL in working memory and later episodic memory formation, specifically exploring the nature of the mnemonic processes mediated by distinct sub-regions within PFC and MTL. It is hypothesized that a process-based organization is present in both PFC and MTL such that the maintenance of information will be neurally dissociable from the manipulation of and integration across items. Experiment 1 will examine whether there is a similar process basis for the recruitment of PFC and MTL, using event-related functional magnetic resonance imaging (fMRI) analyses to identify regions that predict later item-based and relational memory. Experiment 2 will investigate the nature of ventrolateral and dorsolateral PFC operations by exploring how interference modulates PFC activation. Experiments 3-4 will examine if process-specific activation in PFC and MTL generalizes across learning and test contexts by distinguishing between regions that are associated with memory for an item and those associated with memory for the association between an item and its context and/or source. These studies should serve to elucidate the nature of and commonalities between PFC and MTL mnemonic processes, furthering our understanding of these critical structures that are susceptible in Alzheimer?s and Parkinson?s disease, Schizophrenia, and healthy aging.