Mechanically Chiral Rotaxanes in Catalysis, Sensing and Materials

轮烷和链烷是典型的互锁分子，轮烷中的线性成分被捕获在环状分子中，就像线上的珠子一样；环烷是由两个环相互连接而成的分子，就像链上的链接一样。像这样将分子组分结合在一起会极大地改变它们的性质，并导致新的功能和应用。事实上，大自然已经利用这种方法稳定了顺丁烯结构中的DNA(自然1967)和作为轮烷的多肽(ACC)。化学。决议2015)。有关机械互锁分子的性质的介绍，请参阅：“链烷和轮烷中机械键合的化学后果”(化学。交警。2014年)。在这个项目中，我们将使用Goldup Group(J.Am)开发的尖端技术化学。SoC。2018)基于塔瓦索利集团开发的人工生物活性分子合成轮烷和环戊烷(《自然化学2017》)，并展示其作为化学生物学新工具的应用。

Rotaxanes, in which a linear component is trapped within a ring-shaped molecule like a bead on a thread, and catenanes, molecules formed of two rings threaded through one another like links in a chain, are the archetypal interlocked molecules. Holding the molecular components together like this changes their properties considerably and leads to new functions and applications. Indeed, nature has taken advantage of this approach to stabilise DNA in catenane structures (Nature 1967) and peptides as rotaxanes (Acc. Chem. Res. 2015). For an introduction to the properties of mechanically interlocked molecules see: "Chemical consequences of mechanical bonding in catenanes and rotaxanes" (Chem. Commun. 2014). In this project we will use cutting edge techniques developed in the Goldup Group (J. Am. Chem. Soc. 2018) to synthesise rotaxanes and catenanes based on artificial biologically active molecules developed by the Tavassoli Group (Nature Chemistry 2017) and demonstrate their application as new tools for chemical biology.