Novel Pyrogen Removal System

说明(由申请人提供)：需要无热原水(PFW) 许多应用程序。实验室将其用作化合物制备的溶剂， 培养基及设备清洗。医院用它进行清洁，以备 用于注射、左心室和血液透析的解决方案。制药商 用于配制注射用药物制剂。热原，或发烧诱导剂， 来自细菌、霉菌、酵母菌、病毒和 某些化学物质。 目前用于制备PFW的技术包括蒸馏、反渗透、 和超滤。总体而言，这些过程很复杂，容易失败， 在许多情况下，不能去除足够的热原，对于小的 规模化设施。在这个项目中，紧凑型膜系统(CMS)具有 确定了一个简单的(一键式)系统，可轻松集成到 现有的热原去除系统。 CMS技术的基础是一种新的氧化系统，既能杀死 并氧化它们的内毒素。在第一阶段，我们将发展这一点 新型氧化系统，表现出比传统氧化系统更好的热原去除效果 现有技术。 建议的商业应用： 注射用水包括肾透析用水和药用水。

DECRIPTION (Provided by applicant): Pyrogen-free water (PFW) is required in many applications. Laboratories use it as solvent for compound preparation, culture media, and equipment rinse. Hospitals use it for cleaning to prepare solutions for injections, lV's, and hemodialysis. Pharmaceutical manufacturers use it to formulate injectable drug preparations. Pyrogens, or fever-inducers, are derived from metabolic byproducts of bacteria, molds, yeasts, viruses, and certain chemicals. Current technology used to prepare PFW include distillation, reverse osmosis, and ultrafiltration. Overall these processes are complicated, prone to failure, and in many cases do not remove sufficient pyrogens and are not ideal for small scale facilities. In this program, Compact Membrane Systems (CMS) has identified a simple (push one button) system that is easily integrated into existing systems for pyrogen removal. The basis of the CMS technology is a novel oxidizing system that both kills microorganisms and oxidizes their endotoxins. In Phase I we will develop this novel oxidizing system and demonstrate superior pyrogen removal compared to existing technologies. PROPOSED COMMERCIAL APPLICATION: Water for Injection including Kidney Dialysis water and pharmaceutical water.