Novel Optical Probe for Oral and Dental Tissue Screening

描述：目前正在开发一种新型的光学探头，用于 生化和生物化学的非侵入性表征和监测 口腔上皮细胞的形态变化导致异型增生和 最终发展为浸润性鳞状细胞癌。口腔鳞状细胞癌是 一种情况，它将导致大约一半的患者死亡 五年的诊断，可能会给幸存的患者留下严重的审美障碍 或者功能上的妥协。大约31,000名美国人患上口腔癌 每年。口腔癌通过一系列的形态变化而发展， 如果及早发现和治疗，可以极大地改善预后和 生死存亡。口腔和牙科领域的临床医生在 口腔癌的早期检测，目前的应用寻求开发一种 帮助这些临床医生进行准确筛查和诊断的工具。 在之前的第一阶段SBIR工作中，荧光图像引导光学 相干断层扫描(FIG-OCT)探头，能够同时采集和 组织自发荧光和光学相干层析成像(OCT)的联合配准 图像，是设计和建造的。荧光成像提供了高度的 灵敏快速的口腔筛查手段，而OCT的能力 为了阐明高分辨率次表层形态特征导致 比自发荧光具有更高特异度的卓越诊断技术 光是想象而已。在口腔癌的仓鼠模型中，它成功地 证明了FIG-OCT是一种快速、准确的口腔检查技术 癌症筛查。当前的阶段1应用程序提出了适应这一点的计划 形成一种形式，可以使用，用于初步临床 在人类身上进行研究。 建议的商业应用：不可用

DESCRIPTION: Currently under development is a novel optical probe for non-invasive characterization and monitoring of the biochemical and morphological changes in oral cavity epithelium leading to dysplasia and ultimately to invasive squamous cell carcinoma. Oral squamous cell carcinoma is a condition, which will kill approximately half of patients afflicted within five years of diagnosis and may leave surviving patients with severe aesthetic or functional compromises. Approximately 31,000 Americans develop oral cancer each year. Oral cancer progresses through a series of morphologic changes, which, if detected and treated early, can vastly improve prognosis and survival. Clinicians in the oral and Dental fields play an important role in early detection of oral cancer, and the current application seeks to develop a tool to aid these clinicians in accurate screening and diagnosis. During a previous Phase 1 SBIR effort, a fluorescence image guided optical coherence tomography (FIG-OCT) probe, capable of simultaneously acquiring and co-registering tissue autofluorescence and optical coherence tomography (OCT) images, was designed and built. Fluorescence imaging provides a highly sensitive and rapid means for oral cavity screening, while the ability of OCT to elucidate high-resolution sub-surface morphological features leads to a superior diagnostic technique with higher specificity than autofluorescence imaging alone. In a hamster model of oral cancer, it was successfully demonstrated that FIG-OCT resulted in a rapid and accurate technique for oral cancer screening. The current Phase 1 application presents plan to adapt this instrument into a form, which can be used, for preliminary clinical investigation in humans. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE