Catalytic Enantioselective 1,2-Rearrangements Using Lewis Base Catalysis

开发有效的催化对映选择性方法以从廉价、容易获得且可持续的化学结构单元制备对映体纯的定制α-氨基酸衍生物是精细化学工业的重大挑战。受此需求的启发，本项目旨在开发多功能和最先进的方法，用于催化对映选择性合成功能化α-氨基酸。该项目将为通过烯丙基铵叶立德的[1，2]-重排催化对映选择性合成功能化α-氨基酸衍生物提供最先进的解决方案。结合动力学和机械研究，这将提供一个刺激和具有挑战性的CRITICAT博士项目。

The development of efficient catalytic enantioselective methods to prepare enantiomerically pure bespoke a-amino acid derivatives from cheap, readily available and sustainable chemical building blocks is a significant challenge for the fine chemical industry. Inspired by this need, this project aims to develop versatile and state-of-the-art methodologies for the catalytic enantioselective synthesis of functionalised a-amino acids. This project will provide state-of-the-art solutions to the catalytic enantioselective synthesis of functionalised a-amino acid derivatives through the [1,2]-rearrangement of allylic ammonium ylides. Combined with kinetic and mechanistic studies this will provide a stimulating and challenging CRITICAT PhD project.