CORE--BIOSTATISTICS FACILITY

描述(由申请者提供)：生物统计学核心设施带来 结合生物统计学、临床和医学领域的专业知识和智力资源 试验、流行病学、统计计算、数据库和信息 管理层。核心基金广泛参与了对癌症的支持 临床试验、预防和癌症控制研究中心， 基因和种群研究，以及翻译研究。活动 包括：1)方案制定；2)方案审查；3)研究监测；4) 数据分析和报告；5)数据库开发和管理；6) 具有大型人口数据库的应用程序；7)数据服务和计算机 编程；8)与研究相关的网站开发；9)教育；和10) 统计咨询和协作。核心设施密切相关 支持临床试验股的活动。生物统计学家 积极参与作为临床试验一部分的所有方案的审查 发展和审查委员会。最近核心设施的征聘工作已经完成 增强了对癌症中心活动的生物统计支持，使 树立科研成果要高质量的理念 生物统计学合作。核心基金支持以下活动的活动 癌症研究通过临床试验方案的开发工作得到了说明 在发育治疗学、数据挖掘(基因微阵列数据)、基因 流行病学(如结肠息肉和结肠癌同胞研究)， 行为研究，开发交互式临床试验数据库， 以及探索用于癌症研究的大型人口数据库 提供预防和治疗服务。核心基金已支持 在癌症中心的每个项目中进行研究。核心协作 设施人员与癌症中心调查人员就设计、操作、 对癌症研究的分析和解释提高了 科学。

DESCRIPTION (provided by applicant): The Biostatistics Core Facility brings together expertise and intellectual resources in biostatistics, clinical trials, epidemiology, statistical computing, and database and information management. The Core Facility has wide involvement in support of Cancer Center research in clinical trials, prevention and cancer control research, genetic and population studies, and translational research. Activities include: 1) protocol development; 2) protocol review; 3) study monitoring; 4) data analysis and reporting; 5) database development and management; 6) applications with large population databases; 7) data services and computer programming; 8) research-related website development; 9) education; and 10) statistical consultation and collaboration. The Core Facility closely supports activities of the Clinical Trials Unit. Biostatisticians are actively involved in review of all protocols as part of the Clinical Trials Development and Review Committee. Recent recruitment of the Core Facility has enhanced the biostatistical support of Cancer Center activities, allowing the fostering of the philosophy that productive research requires high quality biostatistical collaboration. Activities of the Core Facility in support of cancer research are illustrated by work on clinical trial protocol development in developmental therapeutics, data mining (genetic microarray data), genetic epidemiology (such as the Colon Polyp and Colon Cancer Sib Pair Study), behavioral research, development of an interactive Clinical Trials Database, and exploration of large population databases for research on cancer preventive and treatment service delivery. The Core Facility has supported research in each of the Programs in the Cancer Center. Collaboration of Core Facility personnel with Cancer Center investigators on the design, operation, analysis, and interpretation of cancer studies has enhanced the quality of the science.