CB: STATISTICS AND INFORMATICS

CB：统计和信息学

• 批准号: 7799149
• 负责人: SYLVAN B. GREEN
• 金额: $ 21.76万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7799149
• 关键词: Analysis of Variance; Area; Arts; Bioinformatics; Biological; Biometry; Clinical; Collaborations; Computer Analysis; Computer Simulation; Computer software; Consultations; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Detection; Drug Delivery Systems; Equation; Experimental Designs; Gene Expression; Genetic Risk; Genome; Goals; Grant; Haplotypes; Human Resources; Informatics; Java; Laboratories; Logistic Regressions; Malignant neoplasm of gastrointestinal tract; Methods; Online Systems; Phase; Procedures; Prognostic Marker; Publishing; Qualifying; Reporting; Reproduction spores; Research Design; Research Personnel; Research Project Grants; Resources; Role; Services; Specialized Program of Research Excellence; Testing; Time; Work; analytical method; cancer genetics; comparison group; computer program; data management; data mining; data sharing; falls; genome sequencing; meetings; protocol development; research study; success; tool; web site

Core B will provide essential statistical, computational, and informatics expertise that will be necessary for all Gl SPORE projects and investigators to achieve the translational goals of the SPORE grant in a timely and efficient manner. Core B personnel are expertly qualified for this task and represent a broad spectrum of capability in biostatistics and computational analysis. They contributed significantly to the Gl SPORE projects in the previous grant period through extensive interactions with SPORE investigators and have been actively involved with experimental design and analysis for each project in this competing renewal application. Core B contributions will fall into two main areas, biostatistics and informatics. Biostatistical analysis includes descriptive analysis of data, hypothesis testing, group comparisons using t- tests or analysis of variance, linear and logistic regression, zero-inflated Poisson regression, Generalized Estimating Equations, and assessment of relationships between time and potential clinical, laboratory, and treatment covariates. Transformations are used as needed to meet statistical assumptions and,when such transformations are not available, nonparametric procedures are used. False discovery rates are estimated to compensate for multiple comparisons common in high throughput data analysis. Biostatistical input also includes an essential role in planning of projects, study design, and protocol development. Informatics-includes web sites for data storage and information sharing, data management support, bioinformatics support for sequence and genome analysis, software methods for finding and validating predictive markers and drug targets, haplotype analysis, advanced computational modeling of large data sets, and biological interpretation of microarray and high-throughput data. Core B personnel are expert data managers and perl/java/R programmers prepared to meet the computational needs of the SPORE grant. The combined biostatistical and informatics expertise of Core B thus offers a full range of data analysis and exploratory methods that will be of enormous importance to each SPORE project. This assistance will be made available by regular meetings with SPORE investigators and projects and through Core B service requests. The core Director Dr. Sylvan Green and co-Director Dr. David Mount will work closely together to assure that all requests for Core B collaboration are met in a prompt and effective manner.

核心B将提供必要的统计、计算和信息学专业知识 GL孢子项目和调查人员及时实现孢子赠款的翻译目标 高效的方式。核心B人员熟练地胜任这项任务，代表了广泛的范围 具有生物统计学和计算分析能力。它们对Gl孢子的贡献很大 通过与孢子调查人员的广泛互动，在上一个赠款期间开展了项目，并已 积极参与此次竞争性更新中每个项目的实验设计和分析 申请。核心B的捐款将分为两个主要领域，即生物统计和信息学。 生物统计学分析包括数据的描述性分析、假设检验、使用t-检验的群体比较。 方差检验或分析，线性和Logistic回归，零膨胀泊松回归，推广 估计方程，并评估时间与潜在的临床、实验室和 治疗协变量。根据需要使用转换以满足统计假设，并且在 转换不可用，使用非参数过程。估计了错误发现率 以补偿高通量数据分析中常见的多次比较。生物统计学的投入也 包括在项目规划、研究设计和方案制定方面的重要作用。 信息学-包括用于数据存储和信息共享的网站、数据管理支持、 用于序列和基因组分析的生物信息学支持，用于查找和验证的软件方法 预测标记和药物靶标、单倍型分析、大数据高级计算建模 集合，以及对微阵列和高通量数据的生物学解释。核心B人员是专家数据 管理人员和Perl/Java/R程序员准备满足孢子赠款的计算需求。 因此，核心B的生物统计和信息学专业知识提供了全面的数据分析和 对每个孢子项目都非常重要的探索性方法。这项援助将是 通过与孢子调查员和项目的定期会议以及通过核心B服务提供 请求。核心主任西尔万·格林博士和联席主任大卫·蒙特博士将密切合作， 确保以迅速和有效的方式满足所有核心B协作请求。