CB: STATISTICS AND INFORMATICS

CB：统计和信息学

• 批准号: 7600493
• 负责人: SYLVAN B. GREEN
• 金额: $ 21.68万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7600493
• 关键词: Analysis of Variance; Area; Arts; Bioinformatics; Biological; Biometry; Clinical; Collaborations; Computer Analysis; Computer Simulation; Computer software; Consultations; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Detection; Disease regression; Drug Delivery Systems; Equation; Experimental Designs; Gene Expression; Genetic Risk; Genome; Goals; Grant; Haplotypes; Human Resources; Informatics; Internet; Java; Laboratories; Logistic Regressions; Methods; Online Systems; Phase; Procedures; Prognostic Marker; Publishing; Qualifying; Range; Rate; Reporting; Reproduction spores; Research Design; Research Personnel; Research Project Grants; Resources; Role; Services; Site; Testing; Time; Work; analytical method; cancer genetics; comparison group; computer program; data management; data mining; falls; genome sequencing; protocol development; research study; statistics; success; tool

Core B will provide essential statistical, computational, and informatics expertise that will be necessary for all Gl SPORE projects and investigators to achieve the translational goals of the SPORE grant in a timely and efficient manner. Core B personnel are expertly qualified for this task and represent a broad spectrum of capability in biostatistics and computational analysis. They contributed significantly to the Gl SPORE projects in the previous grant period through extensive interactions with SPORE investigators and have been actively involved with experimental design and analysis for each project in this competing renewal application. Core B contributions will fall into two main areas, biostatistics and informatics. Biostatistical analysis includes descriptive analysis of data, hypothesis testing, group comparisons using t- tests or analysis of variance, linear and logistic regression, zero-inflated Poisson regression, Generalized Estimating Equations, and assessment of relationships between time and potential clinical, laboratory, and treatment covariates. Transformations are used as needed to meet statistical assumptions and,when such transformations are not available, nonparametric procedures are used. False discovery rates are estimated to compensate for multiple comparisons common in high throughput data analysis. Biostatistical input also includes an essential role in planning of projects, study design, and protocol development. Informatics-includes web sites for data storage and information sharing, data management support, bioinformatics support for sequence and genome analysis, software methods for finding and validating predictive markers and drug targets, haplotype analysis, advanced computational modeling of large data sets, and biological interpretation of microarray and high-throughput data. Core B personnel are expert data managers and perl/java/R programmers prepared to meet the computational needs of the SPORE grant. The combined biostatistical and informatics expertise of Core B thus offers a full range of data analysis and exploratory methods that will be of enormous importance to each SPORE project. This assistance will be made available by regular meetings with SPORE investigators and projects and through Core B service requests. The core Director Dr. Sylvan Green and co-Director Dr. David Mount will work closely together to assure that all requests for Core B collaboration are met in a prompt and effective manner.

核心B将提供必要的统计、计算和信息学专业知识， Gl SPORE项目和研究人员及时实现SPORE赠款的转化目标， 有效方式核心B人员专业胜任此项任务，并代表广泛的 生物统计学和计算分析能力。他们对Gl孢子的贡献很大 通过与SPORE研究人员的广泛互动，在上一个资助期内完成了项目，并已 积极参与本次竞争性更新中每个项目的实验设计和分析 应用程序.核心B类捐款将分为两个主要领域：生物统计和信息学。 生物统计学分析包括数据的描述性分析、假设检验、使用t检验的组间比较， 检验或方差分析，线性和逻辑回归，零膨胀泊松回归，广义 估计方程，并评估时间与潜在临床、实验室和 治疗协变量。转换是根据需要使用的，以满足统计假设，当这种 转换不可用，则使用非参数程序。错误发现率估计 以补偿在高通量数据分析中常见的多重比较。生物统计输入还 包括在项目规划、研究设计和方案制定方面的重要作用。 信息-包括数据存储和信息共享网站，数据管理支持， 为序列和基因组分析提供生物信息学支持， 预测标记物和药物靶点，单体型分析，大型数据的高级计算建模 集，以及微阵列和高通量数据的生物学解释。核心B人员是专家数据 管理人员和perl/java/R程序员准备满足SPORE赠款的计算需求。 因此，核心B的生物统计学和信息学专业知识相结合，提供了全方位的数据分析， 探索方法，这将是非常重要的每一个孢子项目。这项援助将 通过与SPORE调查人员和项目的定期会议以及通过核心B服务提供 请求。核心主任Sylvan绿色博士和联合主任大卫蒙特博士将密切合作， 确保以及时有效的方式满足所有核心B协作请求。