CORE--CLINICAL BIOCHEMISTRY FACILITY

临床生化设施的目的是为临床化学和生化流行病学提供质量控制分析，以及为AHFCC科学家和项目提供临床协调和生物样本收集和储存。该设施位于两个实验室（总面积约670平方米）。在Naylor Dana研究所的2号单元。该设施的工作人员是一个设施负责人，约翰P里奇，小，博士(10%努力）、实验室主管Steven Colosimo，MS.（100%努力）、临床化学家Allison Muir，B.S. (100%的努力），和临床协调员，劳拉Tolosi，硕士，R.D. (40%努力）。该机构的主要资源包括一台约翰逊和约翰逊Vitros 500大型临床化学分析仪、几台便携式临床化学分析仪、Dynatech 5000 96孔板领导者与Biolinx软件、闪烁计数器、HPLC、GC、自动分析仪和一台自动血液分析仪。该设施提供常规临床化学检测和免疫检测，以及使用收费机制的专业生物化学和生物标志物检测。此外，该设施还参与了用于大规模人体研究的生物标志物开发。我们还通过提供临床协调和生物样本收集和库的专业知识来支持人体研究的实施。癌症中心内的这种专业知识对于实施临床研究至关重要，特别是在需求明显增加的Maylor Dana研究所。特别重要的是，该设施在保密问题上提供帮助，特别是在涉及DNA分析的人类研究中。该设施为所有核心支持的计划以及AHFCC和其他设施内的非编程对齐计划提供服务。每年大约有10-15名AHF同行资助的研究人员以及12-18名外部科学家使用该设施，每年共检测约5，000至10，000份样本。在过去的一年里，该设施的总使用量的90%以上是由AHFCC成员的同行审查资助的项目。

The purpose of the Clinical Biochemistry Facility is to provide quality controlled analyses for clinical chemistry and biochemical epidemiology as well as clinical coordination and biological sample collection and banking for AHFCC scientists and projects. The facility is located in two laboratories (combined space of approximately 670 sq. ft) in Unit 2 at the Naylor Dana Institute. The facility is staffed by a facility head, John P. Richie, Jr., Ph.D. (10% effort), a lab supervisor, Steven Colosimo, MS. (100% effort), a clinical chemist, Allison Muir, B.S. (100% effort), and a clinical coordinator, Laura Tolosi, M.S., R.D. (40% effort). The major resources of the facility include a Johnson & Johnson Vitros 500 Mainframe Clinical Chemistry Analyzer, several portable clinical chemistry analyzers, Dynatech 5000 96 well plate leader with Biolinx software, scintillation counters, HPLCs, GC, auto analyzers and a automated hematological analyzer. The facility offers routine clinical chemistry assays and immunoassays as well as specialized biochemistry and biomarkers tests using a charge-back mechanism. In addition, the facility is involved in biomarker development for use in large-scale human studies. We also support the implementation of human studies by providing expertise in clinical coordination and biological samples collection and banking. This expertise within the Cancer Center is essential for the implementation of clinical studies, particularly at the Maylor Dana Institute where an increasing demand is evident. Of particular important, the facility provides assistance with confidentiality issues especially in human studies involving DNA analysis. This facility provides services to all of the Core-supported programs as well as to non-programmatically aligned programs within AHFCC and at other facilities. Approximately 10-15 peer funded investigators at AHF as well as 12-18 external scientists make use of the facility each year for a total of about 5,000 to 10,000 samples assayed per year. Over the past year, > 90% of the total use of the facility was by AHFCC members' peer- reviewed funded projects.