Chemical Synthesis and Biological evaluation of improved PROTACS based on a novel Design Strategy

该项目涉及一种新的方法来优化一类相对较新的生物活性化合物的活性和物理性质，PROTACs，这是目前实现靶向蛋白质降解的巨大兴趣。有机化学方面包括一系列氟化前体的化学合成，然后掺入protac。药物化学方面包括在我们的工业合作伙伴阿斯利康放置时，对合成的PROTACs与一组医学相关蛋白质进行评估。该项目源于世界领先的有机氟药物化学专业知识。有机合成化学是本项目的重点，它包含了很强的药物化学元素，您将熟悉氟化在当前药物优化中的重要作用。有机合成化学是本项目的重点，它包含了很强的药物化学元素，您将熟悉氟化在当前药物优化中的重要作用，以及新兴的PROTACs领域

The project concerns a novel approach to optimise the activity and physical properties of a relatively new class of bioactive compounds, PROTACs, which are of huge current interest to achieve targeted protein degradation. The organic chemistry aspect consists of the chemical synthesis of a series of fluorinated precursors followed by incorporation into PROTACs. The medicinal chemistry aspect consists of the evaluation of the synthesised PROTACs against a panel of medically relevant proteins while on placement at our industrial collaborator, AstraZeneca. The project originates from the world-leading expertise in organofluorine medicinal chemistry. While synthetic organic chemistry is a key aspect of the project, it contains a strong medicinal chemistry element, and you will become familiar with the significant role of fluorination in current drug optimisation While synthetic organic chemistry is a key aspect of the project, it contains a strong medicinal chemistry element, and you will become familiar with the significant role of fluorination in current drug optimisation and with the burgeoning field of PROTACs