CORE--PATIENT CARE AND TECHNICAL SUPPORT

描述(由申请人提供)：核心B的主要职责是 以提供将在四项研究中研究的患者群体 并为所有项目建立技术和统计支助 调查人员。这四个研究项目高度相互依存， 是相互关联的。每个项目都依赖于 其他项目，以回答他们的具体研究中提出的问题 目标。他们还使用相同的患者群体来解决以下总体目标 临床研究中心以及每个项目的具体目标。这 部分将描述对科目应计项目的广泛的术前评估， 要研究的特定人群，要在治疗期间使用的人工耳蜗 研究方案，以及总体研究设计和时间的一般方法- 受试者牵涉的范围。总体统计设计、数据管理和 讨论了技术支持问题。对具体研究的描述 问题以及每个项目如何交互并依赖于其他项目 都出现在各个项目中。

DESCRIPTION (provided by applicant): The primary responsibilities of Core B are to provide the patient population that will be studied in the four research projects and to establish the technical and statistical support for all investigators. The four research projects are highly interdependent and interrelated. Each project depends on the questions and data generated by the other projects to answer the research questions addressed in their specific aims. They also use the same patient populations to address the overall goals of the Clinical Research Center as well as the specific aims of each project. This section will describe the extensive preoperative evaluation for subject accrual, specific populations to be studied, the cochlear implants to be used during the research protocol, and the general methods of the overall study design and time- line of subject involvement. The overall statistical design, data management and technical support are discussed. A description of the specific research questions and how each project is interactive and dependent on other projects are presented in the individual projects.