EASTERN COOPERATIVE ONCOLOGY GROUP

该提案的总体目标是扩大我们对癌症生物学的了解，利用这些知识为癌症患者设计新的治疗方法，在多机构前瞻性随机临床试验中测试这种新的治疗方法，并通过在科学和医学期刊上发表同行评议以及在科学和医学会议上发表来传播这种试验的结果。这些目标将通过以下方式实现：1）招募患者参加ECOG治疗和其他试验，并及时收集这些试验的准确数据并向ECOG报告，2）在本集团中发挥科学和行政领导作用，3）开展当地临床和实验室试点研究，其结果可作为更大规模ECOG研究的基础，和4）通过利用我们的ECOG参与肿瘤学研究员和初级教师的临床方法学培训。我们在下一个资助期的具体目标是增加ECOG治疗和其他试验的累积，并担任完全或部分基于该机构的试点数据的几项ECOG试验的研究主席，包括血小板生成素在老年急性髓性白血病患者中的研究，茶碱在慢性淋巴细胞白血病中的研究，以及三氧化二砷在复发性急性早幼粒细胞白血病中的研究。此外，建议使用入组ECOG研究组的患者的新鲜和库存样本进行结肠癌、宫颈癌和白血病的实验室研究。

The general aims of the proposal are to expand our knowledge of the biology of cancer, to utilize this knowledge to design new treatments for patients with cancer, to test such new treatments in multi-institutional prospective, randomized clinical trials, and to disseminate the results of such trials through peer review publication in scientific and medical journals, and by presentation at scientific and medical meetings. These aims will be accomplished by 1) accrual of patients to ECOG therapeutic and other trials and by collecting and reporting accurate data from those trials to ECOG in a timely fashion, 2) playing scientific and administrative leadership roles in the Group, 3) conducting local clinical and laboratory pilot studies the results of which may serve as bases for larger ECOG studies, and 4) by utilizing our ECOG participation in the training of oncology fellows and junior faculty in clinical methodology. Our specific aims in the next funding period are to increase accrual to ECOG therapeutic and other trials, and to serve as study chairs of several ECOG trials based entirely or in part on pilot data from this institution, including a study of thrombo-poietin in elderly adults with acute myeloid leukemia, a study of theophylline in chronic lymphocytic leukemia, and a study of arsenic trioxide in relapsed acute pro-myelocytic leukemia. In addition, laboratory investigations in colon cancer, cervical cancer and leukemia utilizing fresh and banked samples from patients enrolled on ECOG studies group wide are proposed.