CORE--ANIMAL MODEL

本核心的目的是在各个项目中提供一致的动物模型制备。 本中心负责为个体研究者准备慢性动物模型。这将减少准备的可变性，并将使各个项目总监从创建这些准备的极度劳动密集型任务中解放出来，并照顾他们的术后立即恢复。各种动物模型将由康沃尔语博士负责制备或在其指导下制备，Cornish博士在慢性动物制备方面具有多年经验，并且在这些特定动物制备方面具有丰富经验。 我们将在两名技术人员的协助下，在各研究者使用动物之前对动物进行准备和护理。 本中心制备的模型为（1）大鼠心力衰竭（HF）冠状动脉结扎模型，（）家兔HF起搏模型，（3）犬HF起搏模型。

The purpose of this Core is to provide a consistent preparation of animal models across the various projects. It will be the responsibility of this Core to prepare the chronic animal models for the individual investigators. This will reduce the variability of preparations and will release the individual project directors from the extremely labor intensive task of creating these preparations and care for their immediate post operative recovery. The various animal models will be prepared by or under the director of Dr. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. We will be assisted by two technicians in the preparation and care of the animals prior to their use by the various investigators. The models prepared by this core will be (1) the coronary ligation model of heart failure (HF) in the rat, () the pacing model of HF in the rabbit, and (3) the pacing model of HF in the dog.