MECHANISM OF SICKLE CELL RETENTION IN THE RETINAL VASCULATURE

改编自申请人的摘要）卢蒂会调查 细胞因子IL-1和TNF α上调细胞表面粘附分子， 人镰状红细胞在视网膜微血管中的滞留 大鼠模型，其中仅保留SS 4细胞（致密SS细胞）， 正常情况下。第二个假设将被调查， 具有较高水平的人α和β S表达的转基因小鼠， 珠蛋白基因具有更早的发病和更严重的视网膜病变， 如果动物接受 LPS，其可能通过机制刺激粘附分子的上调 与大鼠模型中观察到的相似。

Adapted from Applicant's Abstract) PI G. Lutty will investigate the effect of the cytokines IL-1 and TNFalpha which up-regulate adhesion molecules on retention of human sickle erythrocytes in the retinal microvasculature in a rat model in which only SS4 cells (dense SS cells) are retained under normal conditions. A second hypothesis will be investigated that transgenic mice with higher levels of expression of human alpha and BetaS- globin genes have an earlier onset and more severe retinopathy and that the onset of vaso-occlusion occurs more rapidly if the animals receive LPS, which may stimulate up-regulation of adhesion molecules by mechanisms similar to those observed in the rat model.