DNA REPAIR GENE POLYMORPHISMS AND BREAST CANCER RISK

描述(由申请人提供)：研究潜在的基因-环境相互作用可能会提高我们对乳腺癌病因的理解。这项建议的目的是研究DNA修复基因多态与乳腺癌风险之间的关系。在这项建议中，我们假设DNA修复途径在预防乳腺癌发生中发挥重要作用，并且DNA修复基因的多态，如XPD，可能影响乳腺癌的易感性，特别是可能影响电离辐射诱导的致癌。申请人建议通过设计和分析社区队列中DNA修复基因多态与乳腺癌发病率之间的关联的嵌套易控研究来探索这一假设。由于正在进行一项补充研究，申请人还将能够将嵌套病例对照结果与可用于部分人群的队列分析进行比较。这项研究的发现将有助于了解与乳腺癌发生相关的潜在遗传易感因素，并有助于确定哪些乳腺癌风险较高的女性可能受益于有针对性的干预措施。

DESCRIPTION (provided by applicant): Investigations of potential gene-environment interactions may improve our understanding of the etiology of breast cancer. The objectives of this proposal are to examine the association between DNA repair gene polymorphisms and breast cancer risk. In this proposal, we hypothesize that DNA repair pathways play an important role in protecting against breast carcinogenesis, and that polymorphisms in DNA repair genes, such as XPD, may influence breast cancer susceptibility in general, and possibly ionizing radiation-induced carcinogenesis, in particular. The applicant proposes to explore this hypothesis by designing and analyzing a nested ease-control study of the association between DNA repair gene polymorphisms and breast cancer incidence in a community-based cohort. Because of a complementary ongoing study, the applicant will also be able to compare the nested case-control results to a cohort analysis available for a subset of the population. The findings from this study will aid in understanding potential genetic susceptibility factors related to breast carcinogenesis, and in identifying women at increased breast cancer risk who may benefit from targeted interventions.