Mendelian Model Based Inference in Statistical Genetics

描述(申请人提供)：我们将开发S+基因，一个综合性的， 用于分析人类基因数据的易于使用的工具包。我们将包括这两个 精确连锁分析的主要算法：Elston-Stewart算法 允许大的家系，和兰德-格林算法，允许一个 大量的标记基因座。这两种算法都将包括成对和 多点连锁分析，并允许二分和数量性状 和疾病，以及复杂的家谱。我们还将开发软件，用于 双列性状的传递不平衡检验(TDT) 没有或只有很少的数据，而TDT方法用于定量 特征或复杂的疾病，通常是由于 多个遗传位点和环境效应。哈代-温伯格测试和 系谱绘制例程将是该软件包的附加功能。 所有的链接例程和假设检验都将被打包在一个 用户友好的格式，并允许灵活的数据格式。与 其他S+能力，这里提出的S+基因模块将提供 遗传流行病学家拥有一套史无前例的易用工具 分析人类基因数据。 建议的商业应用：不可用

DESCRIPTION (provided by applicant): We will develop S+Gene, a comprehensive, easy-to-use toolkit for analyzing human genetic data. We will include the two main algorithms for exact linkage analysis: the Elston-Stewart algorithm which allows for large pedigrees, and the Lander-Green algorithm which allows for a large number of marker loci. Both algorithms will include pairwise and multipoint linkage analysis, and allow for dichotomous and quantitative traits and diseases, as well as complex pedigrees. We will also develop software for Transmission Disequilibrium Tests (TDT) for dichotomous traits when parental data is not or is only scarcely available, and TDT methods for quantitative traits or complex diseases, which are typically due to a combination of multiple genetic loci and environmental effects. Hardy-Weinberg testing and a pedigree plotting routine will be additional features of this software package. All the linkage routines and hypothesis tests will be packaged in one user-friendly format and allow for flexibility of data-formats. Combined with other S-Plus capabilities, the S+Gene module proposed here will provide the genetic epidemiologist with an unprecedented set of easy-to-use tools to analyze human genetic data. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE