Neurobiology and Cognitive Impairment Of The Elderly

描述(由申请人提供)：项目名称： 《老年人轻度认知障碍的神经生物学》汇集了 来自芝加哥及境外的基础科学家和临床科学家数量 大学。该项目将设在拉什长老会-圣彼得堡。卢克的 芝加哥的医疗中心。该计划项目由一个行政部门组成 具有临床/组织分布部分以及统计和数据的核心 管理核心。此外，还完成了以下四个研究项目 程序：1)Tau、Aβ、突触核蛋白与MCI的硝化/氧化损伤 (John Trojanowski，宾夕法尼亚大学，项目负责人)；2)与年龄有关 老年人的神经病理学和轻度认知障碍(Dennis Dickson， 梅奥诊所，项目负责人)；3)胆碱能基底前脑神经营养 老年人的异常和轻度认知障碍(Elliot Mufson， 项目负责人)；以及突触异常和轻度认知障碍 老年人(史蒂文·德科斯基，匹兹堡大学，项目负责人)。每个人 CORE将支持所有这些研究项目。此外，这些项目 将从NIA资助的Rush ADC收到临床数据和组织样本 所有项目的宗教教团研究核心和神经病理学核心。这个 PPG产生的这些数据的结果将为神经学提供新的线索 有轻度认知障碍的老年人和过渡到AD和 为痴呆症的治疗策略提供新的见解。

DESCRIPTION (provided by applicant): The Program Project entitled "Neurobiology of Mild Cognitive Impairment in the Elderly" brings together a number of basic scientists and clinical scientists from Chicago and outside universities. The project will be based at Rush Presbyterian-St. Luke's Medical Center in Chicago. The Program Project consists of an Administrative Core with a Clinical/Tissue Distribution component and a Statistics and Data Management Core. In addition, the following four research projects complete the program: 1) Tau, A beta, Synuclein and Nitrative/Oxidative Damage in MCI (John Trojanowski, University of Pennsylvania, project leader); 2) Age Related Neuropathology and Mild Cognitive Impairment in the Elderly (Dennis Dickson, Mayo Clinic, project leader); 3) Cholinergic Basal Forebrain Neurotrophic Abnormalities and Mild Cognitive Impairment in the Elderly (Elliot Mufson, Project Leader); and Synaptic Abnormalities and Mild Cognitive Impairment in the Elderly (Steven DeKosky, University of Pittsburgh, project leader). Each core will support all of these research projects. Moreover, these projects will receive clinical data and tissue samples from the NIA funded Rush ADC Religious Orders Study Core and the Neuropathology Core for all projects. The results of this data produced by the PPG will shed new light on the neurology of elderly people with mild cognitive impairment and the transition to AD and provide novel insights into treatment strategies for the onset of dementia.