Renal Molecular Cell Biology Training Program

描述（由申请人提供）：这是一份关于肾脏学培训计划的提案，其目标是培养具有进行肾脏学基础、转化和临床研究所需技能的医生。该计划的一个统一主题是先进的光学显微镜成像技术，用于研究四个广泛的领域：缺血诱导的肾上皮损伤，2)常染色体显性多囊肾病，3)代谢性骨病和4)上皮细胞极性。这个项目旨在增加一个高度积极的教师的动态互动，创造一个高度互动的，令人兴奋的智力环境。该项目目前提供三种途径来培养内科科学家，1)一个为期两年的基础研究要求的肾脏病学培训项目，2)一个由医学部赞助的临床研究员项目提供的博士学位授予项目，3)一个临床研究硕士学位项目。后一个项目的目的是训练研究员执行和完成临床研究项目的细节。该计划从一开始就利用了共同研究主题的医学博士和博士组合教师。由此产生的环境加强了对内科科学家的培训。医学博士提供对疾病相关过程的见解，而博士提供改进的解决问题的见解和对科学数据的严格评估。这一建议旨在建立一个记录，以培训内科科学家和提高教育机会，为肾脏学学员。我们期待招募对肾脏疾病发病机理和分子细胞生物学感兴趣的医学博士和医学博士/博士。根据所选择的培训途径，至少要花三年的时间在这个项目上，最多七年的时间可能会花在攻读博士学位以及肾病亚专业培训上。这个由医生和博士组成的高度互动的小组对肾脏病理生理学有着共同的兴趣。这个项目非常适合有效地招募少数族裔，因为我们的教职员工中有少数族裔的榜样。这项资助将扩展我们的教师与细胞和综合生理学，生物化学/分子生物学，微生物学/免疫学和解剖学/细胞生物学部门的工作关系。通过这样做，我们的教师将增加与研究生，博士后研究员，医学生和住院医生的互动。我们建议每个财政年度培养3名博士后。

DESCRIPTION (provided by applicant):This is a proposal for a nephrology training program whose goal is to develop physicians with the requisite skills to perform basic, translational and clinical research in nephrology. A unifying theme for the program is advance light microscopy imaging techniques which is utilized to study four broad areas;) ischemia induced renal epithelial injury, 2) autosomal dominant polycystic kidney disease, 3) metabolic bone disease and 4) epithelial cell polarity. This program seeks to increase the dynamic interactions of a highly motivated faculty that has created a highly interactive, intellectually excitng environment. This program now offers three pathways to train physician-scientist, 1) a nephrology training program with a two-year basic research requirement, 2) a PhD degree granting program offered through the Department of Medicine's ABIM sponsored Clinician Investigator program and 3) a Masters in Clinical Research degree program. The later program is designed to train fellows in the details of performing and completing clinical research projects. This program from its inception has utilized combined faculty of MDs and PhDs working on common research themes. The resulting environment has resulted in enhanced training for physician-scientists. MDs provide insights into disease-related processes while PhDs offer improved problem solving insights and rigourous evaluation of scientific data. This proposal seeks to build upon a record to training physician-scientists and to enhance the educational opportunities for nephrology trainees. We envision recruitment of MDs and MD/PhDs with an interest in renal disease pathogensis and molecular cell biology. Depending upon the training pathway selected, a minimum of three years will be spent in the program and up to seven years may be spent in the pursuit of a PhD degree along with Nephrology subspeciality training. This highly interactive group of physicians and PhDs share common interest in renal pathophysiology. The program is idealy suited to effectively recruit under represented minorities, since we have minority role models on the faculty. This grant will extend the working relationships of our faculty with the departments of Cellular and Integrative Physiology, Biochemistry/Molecular Biology, Microbiology/Immunology and Anatomy/Cell Biology. By doing so, our faculty will increase their interactions with graduate students, post-doctoral fellows, medical students and medicine residents. We propose to train three postdoctoral fellows each fiscal year.