CORE--NEUROSCIENCE CORE

描述(由申请人提供)： 该计划项目的目标是利用最先进的行为、神经解剖学和 电生理学和血流动力学方法研究认知的神经基础。 趋同的实验方法将增强我们对所研究的认知过程的时空特性的理解。《核心》首先介绍了行政结构和主要人员，然后概述了研究环境。然后，核心描述了执行控制、记忆和语言项目共有的研究方法和基础设施。提供了对患者的详细描述，以及用于选择和定义所有研究对象的神经和行为状态的方法。提供了定义病变的神经解剖学方法，包括皮质损伤的程度和绘制白质束恶化的新技术。最后，对可能采用的生理学技术，包括脑电/事件相关电位和功能磁共振成像技术进行了全面的综述。该核心还将支持探索神经解剖损伤重建、脑电和功能磁共振数据融合的新方法。该核心还将描述在使用功能磁共振方法对神经科患者进行研究时需要考虑的参数。核心所提供的基础设施将提供 研究人类正常和神经学认知所需的先进神经生物学工具 受损害的人口。

DESCRIPTION (provided by applicant): The aim of this Program Project is to employ state of the art behavioral, neuroanatomical, and electrophysiological and hemodynamic methodologies to study the neural basis of cognition. Converging experimental approaches will enhance our understanding of the spatio-temporal properties of the cognitive processes under investigation. The Core initially describes the administrative structure and key personnel and then provides an overview of the research environment. The Core then delineates the research methodologies and infrastructure common to the Executive Control, Memory and Language Projects. A detailed description of the patients is provided as well as the methods used for selection and definition of the neurological and behavioral status of all research subjects. Neuroanatomical methods for lesion definition including extent of cortical damage and new techniques for mapping white matter tract deterioration are provided. Finally, physiological techniques to be employed including EEG/ERP and fMRI procedures are comprehensively reviewed. The Core will also support exploration of novel methods for neuroanatomical lesion reconstruction, fusion of EEG and fMRI data. The Core will also delineate parameters that will need to be considered in the study of neurological patients with fMRI approaches. The infrastructure provided in the Core will provide the advanced neurobiological tools necessary to study human cognition in normal and neurologically impaired populations.