UCSFCC/SFSU Collaborative Cancer Research and Training

本协作组由加州大学旧金山癌症中心(UCSFCC)和旧金山州立大学(SFSU)联合开展。它将启动两个试点研究项目和两个规划和发展活动，为未来的合作博士前研究培训。试点研究项目将涉及两个SFSU/UCSFCC调查团队；这两个团队都是在新聘用的SFSU生物学助理教授和同时也是UCSFCC成员的加州大学旧金山分校高级教员之间进行的，加州大学旧金山分校教授伊丽莎白·布莱克本博士将作为导师和共同研究员，与Sally Psience博士一起研究分裂酵母DNA复制和修复突变体中的端粒末端。Wilfred DenetClaw博士(被任命为旧金山州立大学生物学助理教授，自2000年9月起生效)将由这位前加州大学旧金山分校博士后导师Charles Ordahl教授指导。他们的合作研究项目将专注于皮肤肌瘤肌小节前体细胞的生物标记物以及它们从上皮到间充质向肌小肌层的转变。每个协作试点项目的研究问题和指导承诺都是为了在P-20规划赠款的第三年期间提交RO1提案而设计的。学生研究培训将是本提案规划和发展部分的重点。一项试点规划与开发活动将利用SFSU和UCSFCC教师队伍，专门为SFSU本科生(MARC和MBRS-RISE)和SFSU MA/MS学位(NIH Bridge和MBRS-RISE)学生制定更积极和协调的安置流程/计划。为了在2001年6月开始这项活动，合作的教师规划委员会审查和评估了过去参与加州大学旧金山分校本科生(MARC和MBR-RISE)在加州大学旧金山分校的夏季研究经验和2)其学术论文研究是在加州大学旧金山分校教职员工实验室执行的，并制定了行动计划，将在充满癌症重点的环境中发展强大的研究培训经验。第二项试点规划和发展活动将针对在该P-20项目的第三年期间提交R-25E或R-25T或T-32博士前培训联合提案。要实现这一目标，需要通过UCSFCC-SFSU联合教职员工会议和务虚会进行认真规划，以1)确定短期和长期博士前学生癌症研究培训目标并确定其优先顺序，2)根据R-25E或R-25T或T-32资助机制的指导，制定双方都能接受的协作式博士前癌症研究培训计划。任何最终提案的一个核心要素将是应用招聘和保留战略，这将导致在博士项目中招收人数不足的少数族裔人数增加。

DESCRIPTION This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Developmental activities for future collaborative pre-doctoral research training. The pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations is between a newly hired SFSU Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC, UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentored and co-investigator with Sally Passion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutants. Wilfred Denetclaw, Ph.D. (Appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by this former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments build into each collaborative pilot project are designed to test in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Developmental components of this proposal. One pilot Planning and Development activity will use a cohort of SFSU and UCSFCC faculty to develop a more aggressive and concerted placement process/program for SFSU undergraduate (MARC and MBRS-RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically. In order to commence this activity in June 2001, the collaborative faculty planning committee review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS-RISE) in summer research experiences in UCSF and 2) whose academic thesis research was executed in UCSF faculty laboratories and develop an action plan that will develop a strong research training experience in an environment permeated with a cancer focus. The second pilot Planning and Development activity will be directed at the submission of a joint R-25E or R-25T or T-32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre- doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre-doctoral cancer research training program with the guidelines of the R-25E or R-25T or T-32 funding mechanisms. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented minorities in Ph.D. programs.