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Archiving the Charleston Heart Study

Archiving the Charleston Heart Study
查尔斯顿心脏研究存档
批准号：
6533526
负责人：
Paul J Nietert
金额：
$7.3万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-08-01 至 2004-07-31
来源：
https://reporter.nih.gov/project-details/6533526
关键词：
African American aging archives behavior cardiovascular disorder risk caucasian American clinical research coronary disorder epidemiology functional ability gender difference human data human middle age (35-64) human old age (65+) information dissemination longitudinal human study racial /ethnic difference social psychology socioeconomics vital statistics

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项目成果

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中文摘要
翻译
描述（由申请人提供）：将查尔斯顿心脏研究（CHS）收集的41年期间（1960-2000）的数据存档，将有助于重要的研究工作，旨在了解基于社区的队列中衰老的自然进程。通过对这一独特数据集的二次数据分析，可以增强与老龄化双种族社区队列的社会经济和行为特征相关的当前科学知识。CHS从1960年开始随机招募35岁及以上的社区居民，包括男性和女性，黑人和白人。最初研究的主要假设是调查冠状动脉疾病的表现和危险因素的种族差异。在随后的40多年里，各种结果测量被纳入对参与者的重新检查，包括心理社会，行为，衰老和功能测量。本应用程序的目的是记录和保存查尔斯顿心脏研究，以供未来的研究工作使用，更新队列的重要状态，并建立将数据和文件分发给研究人员的机制，以促进其使用，并提供用户支持和技术服务。将这些纵向数据存档以供将来的科学使用，将确保为后续研究提供必要的基础，以扩大对衰老风险因素、相关因素和后果的科学知识，同时允许探索假定风险因素和结果表现中的种族差异。
英文摘要
DESCRIPTION (provided by applicant): Archiving the Charleston Heart Study (CHS) data collected over a 41-year period (1960-2000) will facilitate important research efforts directed toward understanding the natural progression of aging in a community based cohort. Enhancement of current scientific knowledge related to the socioeconomic and behavioral characteristics of an aging biracial community cohort may be possible through secondary data analyses of this unique data set. The CHS began enrolling a random selection of community residents in 1960 who were then 35 years of age and older - including men and women, black and white. The primary hypothesis of the original study was to investigate racial differences in the manifestation and risk factors for coronary disease. Over the ensuing 40+ years, a variety of outcome measurements were incorporated into the reexamination of the participants, including psychosocial, behavioral, aging and functional measures. The aims of this application are to document and preserve the Charleston Heart Study for future research efforts, to update the vital status of the cohort, and to establish mechanisms for distributing the data and documentation to researchers in a manner that will facilitate its use, and provide user support and technical services. Archiving this longitudinal data for its future scientific use will ensure the necessary foundation for subsequent studies to expand scientific knowledge of the risk factors, correlates and consequences of aging, while simultaneously allowing for exploration of racial disparity in the manifestation of putative risk factors and outcomes.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.
DOI： 10.1001/jama.2009.1063
发表时间： 2009-07-22
期刊： JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
影响因子： 120.7
作者： [Erqou, Sebhat, Kaptoge, Stephen, Perry, Philip L., Di Angelantonio, Emanuele, Thompson, Alexander, White, Ian R., Marcovina, Santica M., Collins, Rory, Thompson, Simon G., Danesh, John]
通讯作者： Danesh, John
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies.
DOI： 10.1016/s0140-6736(10)60484-9
发表时间： 2010-06-26
期刊： LANCET
影响因子： 168.9
作者： [Sarwar, N., Gao, P., Seshasai, S. R. Kondapally, Gobin, R., Kaptoge, S., Di Angelantonio, E., Ingelsson, E., Lawlor, D. A., Selvin, E., Stampfer, M., Stehouwer, C. D. A., Lewington, S., Pennells, L., Thompson, A., Sattar, N., White, I. R., Ray, K. K., Danesh, J., Tipping, R. W., Ford, C. E., Pressel, S. L., Folsom, A. R., Chambless, L. E., Wagenknecht, L. E., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Stefanadis, C., Knuiman, M., Whincup, P. H., Wannamethee, S. G., Morris, R. W., Kiechl, S., Willeit, J., Oberhollenzer, F., Mayr, A., Wald, N., Ebrahim, S., Yarnell, J. W., Gallacher, J., Casiglia, E., Tikhonoff, V., Nietert, P. J., Sutherland, S. E., Bachman, D. L., Keil, J. E., de Boer, I. H., Kizer, J. R., Mukamal, K. J., Tybjaerg-Hansen, A., Nordestgaard, B. G., Benn, M., Frikke-Schmidt, R., Giampaoli, S., Palmieri, L., Panico, S., Vanuzzo, D., Pilotto, L., de la Camara, A. Gomez, Rubio, M. A., Simons, L., McCallum, J., Friedlander, Y., Fowkes, F. G. R., Lee, A. J., Taylor, J., Guralnik, J. M., Phillips, C. L., Wallace, R., Guralnik, J. M., Phillips, C. L., Blazer, D. G., Guralnik, J. M., Phillips, C. L., Phillips, C. L., Guralnik, J. M., Khaw, K. T., Brenner, H., Raum, E., Mueller, H., Rothenbacher, D., Jansson, J. H., Wennberg, P., Nissinen, A., Donfrancesco, C., Giampaoli, S., Salomaa, V., Harald, K., Jousilahti, P., Vartiainen, E., Woodward, M., D'Agostino, R. B., Vasan, R. S., Fox, C. S., Pencina, M. J., Bladbjerg, E., Jorgensen, T., Moller, L., Jespersen, J., Dankner, R., Chetrit, A., Lubin, F., Wilhelmsen, L., Eriksson, H., Svardsudd, K., Welin, L., Rosengren, A., Wilhelmsen, L., Lappas, G., Eriksson, H., Bjorkelund, C., Lissner, L., Bengtsson, C., Cremer, P., Nagel, D., Strandberg, T. E., Salomaa, V., Tilvis, R. S., Miettinen, T. A., Tilvis, R. S., Strandberg, T. E., Kiyohara, Y., Arima, H., Doi, Y., Ninomiya, T., Rodriguez, B., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Rimm, E., Pai, J. K., Sato, S., Iso, H., Kitamura, A., Noda, H., Goldbourt, U., Nyyssonen, K., Tuomainen, T. P., Salonen, J. T., Deeg, D., Poppelaars, J. L., Meade, T. W., Cooper, J. A., Hedblad, B., Berglund, G., Engstrom, G., Verschuren, W. M. M., Blokstra, A., Cushman, M., Folsom, A. R., Psaty, B. M., Shea, S., Doring, A., Koenig, W., Meisinger, C., Mraz, W., Verschuren, W. M. M., Blokstra, A., Bueno-de-Mesquita, H. Bas, Wilhelmsen, L., Rosengren, A., Lappas, G., Fletcher, A., Kuller, L. H., Grandits, G., Selmer, R., Tverdal, A., Nystad, W., Gillum, R., Mussolino, M., Rimm, E., Hankinson, S., Manson, J. E., Pai, J. K., Salomaa, V., Harald, K., Jousilahti, P., Vartiainen, E., Cooper, J. A., Bauer, K. A., Davidson, K. W., Kirkland, S., Shaffer, J., Korin, M. R., Kitamura, A., Sato, S., Iso, H., Holme, I., Selmer, R., Tverdal, A., Nystad, W., Ducimetiere, P., Jouven, X., Bakker, S. J. L., Gansevoort, R. T., Hillege, H. L., Crespo, C. J., Palmieri, M. R. Garcia, Amouyel, P., Arveiler, D., Evans, A., Ferrieres, J., Schulte, H., Assmann, G., Westendorp, R. G., Buckley, B. M., Packard, C. J., Sattar, N., Cantin, B., Lamarche, B., Despres, J. P., Dagenais, G. R., Barrett-Connor, E., Wingard, D. L., Bettencourt, R., Gudnason, V., Aspelund, T., Sigurdsson, G., Thorsson, B., Trevisan, M., Witteman, J., Kardys, I., Breteler, M., Hofman, A., Tunstall-Pedoe, H., Tavendale, R., Lowe, G. D. O., Woodward, M., Howard, B. V., Zhang, Y., Best, L., Umans, J., Ben-Shlomo, Y., Davey-Smith, G., Onat, A., Hergenc, G., Can, G., Njolstad, I., Mathiesen, E. B., Lochen, M. L., Wilsgaard, T., Zethelius, B., Riserus, U., Berne, C., Ingelsson, E., Gaziano, J. M., Stampfer, M., Ridker, P., Gaziano, J. M., Ridker, P., Ulmer, H., Diem, G., Concin, H., Tosetto, A., Rodeghiero, F., Manson, J. E., Tinker, L., Liu, S., Howard, B. V., Marmot, I. M., Clarke, R., Collins, R., Fletcher, A., Brunner, E., Shipley, M., Ridker, P., Buring, J., Shepherd, J., Cobbe, S. M., Ford, I., Robertson, M., Ibanez, A. Marin, Feskens, E. J. M., Kromhout, D., Walker, M., Watson, S., Alexander, M., Di Angelantonio, E., Erqou, S., Gao, P., Gobin, R., Haycock, P., Kaptoge, S., Seshasai, S. R. Kondapally, Lewington, S., Pennells, L., Perry, P. L., Ray, K. K., Sarwar, N., Thompson, A., Thompson, S. G., Walker, M., Watson, S., White, I. R., Wood, A. M., Wormser, D., Danesh, J.]
通讯作者： Danesh, J.
Clinical Component
Methodologic Core
Improving Minority Health in Rheumatic Disease (IMHeaRD)
Improving Minority Health in Rheumatic Disease (IMHeaRD)
海外基金