CLINICAL TRIALS NETWORK: PACIFIC NORTHWEST NODE

（申请人摘要）药物依赖仍然是一个持续存在的问题，新的治疗方法，无论是行为还是药物，都在不断地被开发出来。我们非常需要建立一种机制，通过这种机制，一旦这种治疗被证明是有效的，就可以在以社区为基础的治疗项目中广泛应用于临床实践，因为在那里可以看到大量的药物滥用者。然而，研究人员和临床医生之间的一些障碍使这种转变变得困难，如果可能的话。最近医学研究所的报告向我们提出了挑战，要求我们努力“弥合差距”，解决障碍，促进治疗提供者和临床研究人员之间更有效的工作关系，他们有一个共同的目标，想要改善药物滥用治疗及其结果。NIDA制定了一项行动议程，以刺激治疗提供者和研究人员从各自的角度考虑缩小或弥合“差距”的方法。NIDA的行动议程是发展国家临床试验网络（CTN），在该网络中，区域研究和培训中心的研究人员与社区治疗项目合作，为未来的临床研究开发共同感兴趣的领域，并在社区环境中测试有希望的疗法。本提案寻求支持发展太平洋西北（PNW）区域研究和培训中心的nida资助的临床试验网络。该跨学科区域研究和培训中心将设在华盛顿大学酒精和药物滥用研究所（ADAI）内，其主要重点是发展、实施和评估行为和药物疗法，单独或联合使用，针对在现实世界中提供的附属社区治疗项目中的药物使用。它将整合行为学和药理学研究，作为为政策、治疗发展和评估过程提供信息的一种手段，其目标是在更大的临床试验网络中为提高新的和有前途的治疗方法的有效性做出有意义的贡献。研究人员在研究和项目评估方面与社区项目合作，合作开展多地点临床试验，开发和评估药物治疗和行为治疗，开展服务研究，并将结果转化为对临床医生和政策制定者有用的信息。我们将这种经验提供给更大的临床试验网络。

DESCRIPTION: (Applicant's Abstract) Drug dependence continues to be a persistent problem for which new treatments, both behavioral and pharmacological, are continually being developed. There is a great need to develop mechanisms by which such treatments, once shown to be efficacious, can be put into widespread clinical practice in community-based treatment programs where the largest number of drug abusers are seen. A number of barriers between researchers and clinicians, however, have made such a transition difficult, if at all possible. The recent Institute of Medicine report has challenged us to work on "bridging the gap," to address the barriers to facilitate a more functional working relationship between treatment providers and clinical researchers, who share a common goal of wanting to improve substance abuse treatment and its outcomes. NIDA has developed an action agenda to stimulate treatment providers and researchers to consider ways, from each of their perspectives, to narrow or bridge the "gap." NIDA's action agenda is the development of the National Clinical Trials Network (CTN), in which researchers at Regional Research and Training Centers work in partnership with Community-based Treatment Programs both to develop areas of mutual interest for future clinical research and to test promising therapies in community settings. The present proposal seeks support to develop the Pacific Northwest (PNW) Regional Research and Training Center of the NIDA-funded Clinical Trials Network. The interdisciplinary Regional Research and Training Center, to be housed within the University of Washington Alcohol and Drug Abuse Institute (ADAI), will have as its primary focus the development, implementation, and evaluation of behavioral and pharmacological therapies, alone and in combination, targeted at drug use as delivered in the real world settings of the affiliated community-based treatment programs. It will integrate behavioral and pharmacological research as a means of informing policy, therapy development, and the evaluation process, with a goal of contributing meaningfully to the improved effectiveness of new and promising therapies developed within the larger Clinical Trials Network. The investigators have a long history of working with community based programs in research and program evaluation, collaborating on multisite clinical trials, developing and evaluating both pharmacotherapy and behavioral therapy, and conducting services research, and translating and disseminating results into information useful for clinicians and policy makers. It is this experience that we offer to the larger Clinical Trials Network.