AMBLYOPIA IN ASTIGMATIC CHILDREN-DEVELOPMENT & TREATMENT

描述：（申请人摘要）来自科学文献的证据 表明儿童期未矫正的散光与 三种类型的弱视：（1）最佳矫正视力的差异， 正交光栅的对比敏感度（视交叉性弱视或MA），（2） 正交游标视力的最佳矫正视力差异 刺激（也称为MA），以及（3）最佳校正识别的缺陷 （字母）敏锐度。这些数据表明，存在一个敏感期， 发展为弱视相关的弱视。然而，只有有限的信息 关于影响发展和治疗的因素， 弱视相关性弱视 缺乏关于弱视相关性弱视的研究很可能是由于 与大多数儿童散光患病率低有关。然而，在这方面， 大量散光和散光相关的高患病率 弱视已被记录在Tohono O'Odham小学的成员， 儿童目前不佩戴矫正器。存在该 大量未经矫正的高智力儿童样本提供了一个独特的 的发展和治疗的研究机会 弱视相关性弱视 本研究的目的是：（1）描述视力缺陷的特征 与弱视相关的弱视（通过测量光栅 视敏度、游标视敏度、识别视敏度和对比敏感度），（2）至 确定影响弱视发展的因素 (e.g.,诸如散光的量和类型的因素），以及（3）确定 眼镜干预对弱视相关性弱视的年龄效应 这项拟议的研究将提供有价值的临床信息， 弱视的发展和治疗。此外还 将为Tohono O'Odham的成员提供宝贵的公共卫生服务。

DESCRIPTION: (Applicant's Abstract) Evidence from the scientific literature indicates that uncorrected astigmatism during childhood is associated with three types of amblyopia: (1) a difference in best-corrected acuity and contrast sensitivity for orthogonal gratings (meridional amblyopia or MA), (2) a difference in best-corrected acuity for orthogonally-oriented vernier acuity stimuli (also termed MA), and (3) a deficit in best-corrected recognition (letter) acuity. These data suggest the presence of a sensitive period for the development of astigmatism-related amblyopia. However, only limited information is available concerning factors that influence the development and treatment of astigmatism-related amblyopia. The lack of research regarding astigmatism-related amblyopia is most likely due to the low prevalence of astigmatism in most populations of children. However, a high prevalence of large amounts of astigmatism and astigmatism-related amblyopia has been documented in members of the Tohono O'Odham grade-school children are not currently wearing eyeglass correction. The presence of this large sample of uncorrected highly astigmatic children provides a unique opportunity for the study of the development and treatment of astigmatism-related amblyopia. The goals of the present study are: (1) to characterize vision deficits associated with astigmatism-related amblyopia (through measurements of grating acuity, vernier acuity, recognition acuity, and contrast sensitivity), (2) to identify factors influencing the development of astigmatism-related amblyopia (e.g., factors such as amount and type of astigmatism), and (3) to determine age-specific effects of glasses intervention on astigmatism-related amblyopia. The proposed study will provide valuable clinical information regarding the development and treatment of astigmatism-related amblyopia. In addition, it will provide a valuable public health service to members of the Tohono O'Odham.