NEURAL BASIS FOR RECOVERY OF FUNCTION AFTER STROKE

描述：这个项目的长期目标是检查神经 中风后运动功能恢复的基础及疗效观察 康复训练方案对神经生理和行为结果的影响。 这些研究将使用神经生理学和行为训练技术 成年灵长类动物检查初级运动的功能重组 局灶性血管梗死后大脑皮质及康复治疗的影响 关于重组的范围和时间进程的再培训程序 运动功能恢复。汽车地图将在不久之前和不久进行比较 局灶性血管梗死后。将解决四个具体目标。目标1 将检查恢复期运动模式的变化，并 在完整的运动皮质中发生的神经生理学变化。本研究 应该阐明运动恢复是否是 重新学习中风前使用的运动模式，或者是学习的结果 新颖的代偿性运动模式。目标2将评估以下项目的有效性 不同康复训练方案对术后运动功能恢复的优化 卒中。虽然许多康复程序目前用于人类 对于中风患者，这项研究可以确定产生最佳效果的程序 运动皮质的功能重组和最佳运动恢复。目标 3将考察重复的手工技能训练对运动地图的影响 以及大面积脑梗塞后的运动恢复。以前的研究使用 这个猴子模型使用了非常小的梗塞。目前还不知道这是否重复 当更大体积的皮质组织受伤时，训练是有效的。目标 4将在一年后检查延迟重复训练的有效性 卒中。培训程序将在一个月或三个月内实施 在大面积的缺血性脑梗塞后。这项研究将确定是否有一个 开始康复训练的最佳时机，以便 最大限度地提高运动皮质的适应性可塑性以及运动恢复能力。 这些研究的目的是提供临床上对 卒中后康复过程及其对神经生理学的影响 康复。神经生理学重组与脑出血的相关性研究 脑损伤后的功能恢复最终可能导致新的方法 为了康复医学。

Description: The long-term goals of this project are to examine the neural bases for recovery of motor function after a stroke and the effectiveness of rehabilitative training regimens on neurophysiologic and behavioral outcomes. These studies will use neurophysiologic and behavioral training techniques in adult primates to examine functional reorganization in the primary motor cortex after focal vascular infarct and the effects of rehabilitative retraining procedures on the extent and time course of reorganization and on functional motor recovery. Motor maps will be compared before and shortly after focal vascular infarct. Four specific aims will be addressed. Aim 1 will examine alterations in movement patterns during the recovery period and neurophysiologic changes that occur in the intact motor cortex. This study should shed light on the question of whether motor recovery is the result of relearning motor patterns used prior to stroke, or is the result of learning novel, compensatory motor patterns. Aim 2 will assess the effectiveness of different rehabilitative training regimens to optimize motor recovery after stroke. While many rehabilitative procedures are currently used in human stroke patients, this study could identify procedures which produce optimal functional reorganization in the motor cortex and optimal motor recovery. Aim 3 will examine the effects of repetitive manual skill training on motor maps and motor recovery following large ischemic infarcts. Previous studies using this monkey model used very small infarcts. It is not known if repetitive training is effective when a larger volume of cortical tissue is injured. Aim 4 will examine the effectiveness of delayed repetitive training after a stroke. Training procedures will be introduced either one or three months after a large ischemic infarct. This study will determine if there is an optimal window of opportunity to begin rehabilitative training in order to maximize adaptive plasticity in the motor cortex as well as motor recovery. These studies are designed to provide a clinical understanding for the recovery process after a stroke and the neurophysiologic effects of rehabilitation. The correlation of neurophysiologic reorganization with functional recovery after brain damage could eventually lead to new approaches to rehabilitative medicine.