CORE--MOUSE BMT CORE

描述：(申请者描述)核心B被设计为鼠标BMT核心。它将提供集中服务，确保与项目1的顺利协调，并加强项目2、项目3和项目4的主要调查人员及时进行骨髓移植的能力，并对试剂、骨髓移植调节和治疗干预进行足够的质量控制。它还将确保实验在所有这些项目中都是可重复的。这一核心是方案项目赠款目标的核心，并确保将这些项目的分析作为一个整体协调和整合到方案中。这个核心实现了各种项目的努力，以维持一个实验上相互依赖的计划。此外，由于专业知识和管理是集中的，因此可以在技术协议方面实现显著的工作节约，以及最大限度地减少鼠标购买和每日成本。

DESCRIPTION: (Applicant's Description) Core B is designed as the mouse BMT core. It will provide a centralized service that will ensure smooth coordination with Project 1, as well as enhancing the ability of the principal investigators on Projects 2, 3, and 4 to perform bone marrow transplantations in a timely manner and with sufficient quality control of reagents, BMT conditioning, and therapeutic interventions. It will also ensure that experiments will be reproducible among all these projects. This core is central to the goal of the program project grant and ensures the coordination and integration of analyses of these projects into the program as a whole. This core realizes the various projects' efforts to sustain an experimentally interdependent program. In addition, because the expertise and administration is centralized, a significant economy of effort can be achieved with respect to technical protocols, as well as minimization of mouse purchasing and per diem costs.