Blood and Marrow Transplant State of the Science Symposium

描述（由申请人提供）： 该提案寻求对将于2007年6月26日至27日在密歇根州安阿伯举行的造血细胞移植（HCT）“科学现状”研讨会的组织支持。每年进行数千次HCT以治疗恶性和非恶性疾病。目前估计全世界每年的HCT数量约为45，000例，美国每年约为15- 20，000例。增加使用的原因包括在许多疾病中已证实和潜在的疗效，更好地了解适当的时机和患者选择，更好的供体可用性和更好的技术来确定HLA匹配，更容易收集干细胞，以及改善支持性护理。尽管有这些改进，HCT的应用仍然受到相对高的发病率和死亡率风险的限制，并且在同种异体HCT的情况下，合适供体的可用性。2001年，美国国家心脏、肺和血液研究所（NHLBI）和美国国家癌症研究所（NCI）联合建立了血液和骨髓移植临床试验网络（BMT CTN）。该网络的总体目标是进行临床试验，明确回答当前HCT医疗实践中的关键问题，通过评估多中心环境中的新HCT方法和管理策略来改善患者结局。 本次研讨会的目的是确定BMT CTN在未来五年内可以启动的最引人注目的临床研究机会，并在BMT和血液学科学界传播其结论。的 2000年举行的第一次专题讨论会的建议指导了BMT CTN头五年的科学议程，我们希望第二次专题讨论会的建议同样重要。BMT CTN领导层已经组建了12个委员会，以评估HCT转化和临床研究的最新进展，并已获得该领域12位杰出领导人的同意，担任委员会主席。 重要的是，我们打算公布专题讨论会的建议，并计划在2007年会议和2008年串联会议上口头介绍专题讨论会的主要结论。

DESCRIPTION (provided by applicant): This proposal seeks support for the organization of a "State of the Science" Symposium in Hematopoietic Cell Transplantation (HCT) to be held in Ann Arbor, Michigan on June 26-27, 2007. Thousands of HCTs are performed to treat malignant and non-malignant diseases each year. Current estimates of annual numbers of HCTs are about 45,000 worldwide, with 15-20,000 annually in the United States. Reasons for increasing use include proven and potential efficacy in many diseases, better understanding of appropriate timing and patient selection, greater availability of donors and better techniques for determining HLA match, greater ease of stem cell collection, and improved supportive care. Despite these improvements, application of HCT is still limited by relatively high risks of morbidity and mortality and, in the case of allogeneic HCT, availability of suitable donors. In 2001, The National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI) jointly established a Blood and Marrow Transplant Clinical Trials Network (BMT CTN). The network's overarching goal is to conduct clinical trials that will definitively answer key questions in current HCT medical practice that can improve patient outcomes by assessing novel HCT methods and management strategies in a multi-center setting. The purpose of this symposium is to identify the most compelling clinical research opportunities that can be initiated in the next five years by the BMT CTN, and to disseminate its conclusions among the BMT and Hematology scientific communities. The recommendations of the first symposium, held in 2000, guided the scientific agenda of the BMT CTN during its first five years, and we expect the second symposium's recommendations to be equally important. The BMT CTN leadership has already formed twelve committees to evaluate recent advances in translational and clinical HCT research, and has received agreement from twelve distinguished leaders in the field to act as committee chairpersons. Importantly, we intend to publish the recommendations of the symposium and we plan oral presentations of the symposium's major findings at the 2007 ASH meeting and the 2008 Tandem meeting.