URINE LOSS AND PROLAPSE IN NUNS AND THEIR PAROUS SISTERS

描述（由申请人提供）：本提案是为了响应 RFA：HD-O 0 -012，标题为“女性骨盆底流行病学研究 精神失常。“尿失禁（UT）和盆腔器官脱垂（POP）是 老年妇女常见的健康问题，病因学不清楚 明白阴道分娩时骨盆底受伤， 遗传易感性被认为是与UT相关的因素， 然而，这些关系的流行病学证据很少 也很有争议我们对149名未生育修女的调查研究发现， 压力性尿失禁（SUT）的患病率与 产妇我们建议的研究的主要目的是确定 阴道分娩和家庭关系是否与 尿失禁和盆腔器官脱垂的患病率 客观证实的失禁和脱垂的修女（未经产妇） 在她们的亲生姐妹篇中， 一次阴道分娩为了达到这个目标，我们将： 至少有过一次阴道分娩的亲生姐妹篇;收集数据 从修女和他们的姐妹篇关于UT和POP的任何症状的存在， 以及这些疾病的任何风险因素;并检查了修女和姐妹篇 对于UT和POP的客观证据。检查员将对 主题的身份，以修女或姐妹，并在场或缺席， 症状有UT和POP体征或症状的女性将接受进一步的治疗。 尿动力学检查最后，收集的数据将在一个匹配的 配对分析我们将确定未经生育的修女是否与他们的 在UT和POP方面是生物姐妹篇。一对匹配的logistic 将进行回归，以获得调整后的影响估计， UT和POP中的家庭和阴道分娩，同时考虑其他风险 因素

DESCRIPTION (provided by applicant): This proposal is submitted in response to RFA: HD-O0-012 entitled "Epidemiologic Research on Female Pelvic Floor Disorders." Urinary incontinence (UT) and pelvic organ prolapse (POP) are common health problems in older women, for which the etiologies are poorly understood. Injuries to the pelvic floor at the time of vaginal delivery and genetic predisposition have been implicated as factors associated with UT and POP. However, the epidemiological evidence for these relationships is scant and controversial. Our data from a survey study of 149 nulliparous nuns found the same prevalence of stress urinary incontinence (S UT) as was reported for parous women. The major objective of our proposed study is to determine whether vaginal delivery and familiality are associated with the development of urinary incontinence and pelvic organ prolapse by comparing the prevalence of objectively confirmed incontinence and prolapse in nuns (nulliparous women) with the corresponding rates in their biological sisters who have had at least one vaginal delivery. To achieve this objective, we will: recruit the nuns' biological sisters who have had at least one vaginal delivery; collect data from nuns and their sisters about the presence of any symptoms of UT and POP, and on any risk factors for these conditions; and examined nuns and sisters for objective evidence of UT and POP. The examiner will be blinded to the subjects' identity as to nun or sister, and to the presence or absence of symptoms. Women with signs or symptoms of UT and POP will undergo further urodynamic testing. Finally, the data collected will be tested in a matched pair analysis. We will determine whether nulliparous nuns differ from their biological sisters with regard to UT and POP. A matched pair logistic regression will be performed to obtain an adjusted estimate of the impact of familiality and vaginal delivery in UT and POP, taking into account other risk factors.