Global microbiome analysis of the desert adapted Acomys russatus and Acomys cahirinus.

我们正在寻找一个有创造力和积极性的博士候选人，具有计算生物学背景，加入一个充满活力的多学科研究团队，调查环境和微生物群及其相互作用。该职位由厄勒姆研究所的大卫·蒂伯特博士实验室负责，并与新成立的Quadram研究所的林赛·霍尔博士实验室密切合作。尽管许多研究都集中在饮食和遗传背景对哺乳动物肠道微生物组组成的影响上，但目前对环境对野生哺乳动物的作用知之甚少。环境可以通过食物的可用性影响饮食，进而影响肠道微生物的组成。这个博士生项目的目标是研究和了解肠道微生物群功能和宿主环境之间的关系，通过“干”（生物信息学）和“湿”（基于实验室的）方法使用来自沙漠适应和非适应Acomys物种的宏基因组分析来揭示由于环境引起的宏基因组变异性。

We are looking for a creative and motivated PhD candidate with a background in computational biology to join a dynamic, multi-disciplinary research team investigating the environment and microbiota and interactions. This position is within Dr David Thybert lab at the Earlham institute with a close collaboration with Dr Lindsay Hall's lab at the newly formed Quadram Institute.Although many studies have focused on the effect that diet and genetic backgrounds have on the gut microbiome composition in mammals, very little is currently known on what role the environment has on wild mammals. The environment could influence both diet via food availability and in turn the gut microbe composition.The goal of this PhD studentship is to study and understand the relationship between gut microbiota function and host environment through a mixture of `dry' (bioinformatics) and `wet' (lab-based) approaches using analysis of metagenomes from desert adapted and non-adapted Acomys species to uncover the metagenome variability due to the environment.