RESTORATION OF FUNCTION IN NEUROLOGIC IMPAIRMENT

康复研究所研究公司(RIRC)建议建立一个地区性康复研究网络，名为“神经损伤的功能恢复--研究发展计划”。项目负责人将是W.Z.Rmer医学博士和Elliot Roth医学博士。该计划旨在加强主办机构的康复研究，并扩大范围，加强我们12个州地区的研究。该计划将包括四个核心：一个将是行政管理，其他三个将为我们的12个州的网络提供研究资源。第一个研究核心将是IT核心(张立群博士指导)。该中心将提供机构间通信，并将协助计算机建模和模拟，以及高级信号处理和时间序列分析。第二个将是由Mussa-Ivaldi指导的生物力学/机器人核心，它将提供一系列机器人和单自由度执行器，适合测试神经疾病(包括脊髓损伤和中风)的反射和运动的自愿方面。为了支持我们的临床研究计划，我们确定了一个“临床支持小组”，由三名临床上对神经康复感兴趣的医生组成。这是罗斯医生、陈医生和哈维医生。这些核心将用于支持六个30个月的开发和可行性(D&F)项目，这些项目仿照NIH的R03赠款。巴顿博士(北卡罗来纳州)将研究偏瘫中风患者的运动适应性；格鲁本博士(威斯康星州)将评估骑自行车作为偏瘫男性运动模式的实用性。Kuo博士(密歇根州)将研究控制多功能肌肉中运动单位选择的因素。第二轮D&F将在计划中途提供给我们的网络。为了促进我们12个州中西部地区康复研究的发展，我们邀请了20名网络科学家与我们一起参与。这些来自12个州中10个州的科学家将推荐初级教员进行试点研究，与同事一起开发资助项目，并参加年度审查活动。此外，它们还将用于视频会议，或每季度举行一次基于Web的会议。由堪萨斯医学中心的恩文扎教授和西北大学康复工程研究实验室主任达德利·奇尔德里斯教授共同担任主席的咨询委员会将监测该网络的性能。这些领导人将与从几个康复选区中选出的其他六名领导人一起参加。咨询组还将参与第二轮D&F项目的遴选，并评估研究计划的整体进展。

The Rehabilitation Institute Research Corporation (RIRC) proposes to develop a regional rehabilitation research network called "Restoration of Function in Neurologic Impairment-A Research Development Program". Program directors will be W.Z. Rymer MD Ph.D., and Elliot Roth MD. The program seeks to strengthen rehabilitation research in the host institutions, and to reach out to strengthen research in our 12-state region. The program will include four cores: One will be administrative, and the three others will provide research resources to our 12-state network. The first research core will be an IT core (directed by LiQun Zhang Ph.D.) which will provide inter-institutional communications, and will assist with computer modeling and simulations, and with high-level signal processing and time series analyses. The second will be a Biomechanics/Robotics core, directed by Mussa-Ivaldi which will provide an array of robotic and single degree of freedom actuators suitable for testing reflex and voluntary aspects of movement in neurological disorders, including spinal cord injury and stroke. To support our clinical research programs, we have identified a "clinical support group", made up of three physicians whose clinical interests lie in neuro-rehabilitation. These are Drs. Roth, Chen and Harvey. These cores will be used to support six 30 month Development and Feasibility (D&F) projects, modeled after RO3 grants of the NIH. Dr. Patton (NU) will examine adaptation of movement in hemiplegic stroke; Dr. Gruben (Wisconsin) will evaluate the utility of bicycling as a model of locomotion in hemiplegic man. Dr. Kuo (Michigan) will examine factors governing the selection of motor units in multi-functional muscles. A second round of D & F's will be offered to our network midway through the program. To facilitate the development of rehabilitation research in our 12 state Midwestern region, we have invited 20 network scientists to participate with us. These scientists who are based in 10 of the 12 states will recommend junior faculty for pilot studies, develop funded project with colleagues, and participate in annual review activities. In addition they will be available for video conferencing, or Web base conferences on a quarterly basis. An Advisory Committee, chaired jointly by Professor Enwenza from Kansas Medical center, and Professor Dudley Childress, Director of the Rehabilitation Engineering Research Laboratories at Northwestern University will monitor performance of the network. These leaders will be joined by six others selected from several rehabilitation constituencies. The Advisory group will also participate in the selection of the second round of D & F projects, and evaluate overall progress in the research program.